| Adrenomedullin and pregnancy: perspectives from animal models to humans. | |
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MedLine Citation:
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PMID: 22425034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A healthy pregnancy requires strict coordination of genetic, physiologic and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin (AM) has recently been the focus of some exciting breakthroughs in the pregnancy field. Supported by mechanistic studies in genetic animal models, there continues to be a growing body of evidence demonstrating the importance of AM protein levels in a variety of human pregnancy complications. With more extensive mechanistic studies and improved consistency in clinical measurements of AM, there is great potential for the development of AM as a clinically-relevant biomarker in pregnancy and pregnancy complications. |
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Authors:
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Patricia M Lenhart; Kathleen M Caron |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-03-16 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 23 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2013-02-13 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 524-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cell & Molecular Physiology, The University of North Carolina, Chapel Hill, NC 27599, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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metabolism* Animals Calcitonin Gene-Related Peptide / metabolism Female Fertility / physiology Humans Models, Animal Pregnancy Pregnancy Complications / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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F30 HL104778/HL/NHLBI NIH HHS; HD060860/HD/NICHD NIH HHS; R01 HD060860/HD/NICHD NIH HHS; R01 HD060860-01/HD/NICHD NIH HHS; R01 HD060860-01S1/HD/NICHD NIH HHS; R01 HD060860-02/HD/NICHD NIH HHS; R01 HD060860-03/HD/NICHD NIH HHS; R01 HD060860-04/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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