Document Detail


Adrenomedullin and pregnancy: perspectives from animal models to humans.
MedLine Citation:
PMID:  22425034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A healthy pregnancy requires strict coordination of genetic, physiologic and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin (AM) has recently been the focus of some exciting breakthroughs in the pregnancy field. Supported by mechanistic studies in genetic animal models, there continues to be a growing body of evidence demonstrating the importance of AM protein levels in a variety of human pregnancy complications. With more extensive mechanistic studies and improved consistency in clinical measurements of AM, there is great potential for the development of AM as a clinically-relevant biomarker in pregnancy and pregnancy complications.
Authors:
Patricia M Lenhart; Kathleen M Caron
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-16
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  23     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-13     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin / metabolism*
Animals
Calcitonin Gene-Related Peptide / metabolism
Female
Fertility / physiology
Humans
Models, Animal
Pregnancy
Pregnancy Complications / metabolism*
Grant Support
ID/Acronym/Agency:
F30 HL104778/HL/NHLBI NIH HHS; HD060860/HD/NICHD NIH HHS; R01 HD060860/HD/NICHD NIH HHS; R01 HD060860-01/HD/NICHD NIH HHS; R01 HD060860-01S1/HD/NICHD NIH HHS; R01 HD060860-02/HD/NICHD NIH HHS; R01 HD060860-03/HD/NICHD NIH HHS; R01 HD060860-04/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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