Document Detail

Adrenomedullin: molecular mechanisms and its role in cardiac disease.
MedLine Citation:
PMID:  16583314     Owner:  NLM     Status:  MEDLINE    
Adrenomedullin (AM) is a potent, long-lasting vasoactive peptide originally isolated from human pheochromocytoma. Since its discovery, serum and tissue AM expression have been shown to be increased in experimental models and in patients with cardiac hypertrophy, myocardial infarction and end-stage heart failure with several beneficial effects. Considerable evidence exists for a wide range of autocrine, paracrine and endocrine mechanisms for AM which include vasodilatory, anti-apoptotic, angiogenic, anti-fibrotic, natriuretic, diuretic and positive inotropic. Thus, through regulation of body fluid or direct cardiac mechanisms, AM has additive and beneficial effects in the context of heart disease. Notable molecular mechanisms of AM include cyclic adenosine monophosphate, guanosine-3',5'-monophosphate, PI3K/Akt and MAPK-ERK-mediated cascades. Given the endogenous and multifunctional nature of AM, we consider this molecule to have great potential in the treatment of cardiovascular diseases. In agreement, early experimental and preliminary clinical studies suggest that AM is a new and promising therapy for cardiovascular diseases.
B Yanagawa; N Nagaya
Related Documents :
25171374 - Cardiac overexpression of constitutively active galpha q causes angiotensin ii type1 re...
6344164 - Pathophysiology of irreversible ischemic injury. the border zone controversy.
25354034 - St elevation myocardial infarction: recent advances and updates.
18450834 - Cardiac stimulation with high voltage discharge from stun guns.
24774664 - Post-infarction ventricular tachycardia with a qrs complex narrower than 140 ms: charac...
6537794 - Angiosarcoma of the heart. unusual presentation and survival after treatment.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-04-04
Journal Detail:
Title:  Amino acids     Volume:  32     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-05     Completed Date:  2007-11-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
1-Phosphatidylinositol 3-Kinase / metabolism
Adrenomedullin / metabolism*,  therapeutic use
Cardiotonic Agents / metabolism*,  therapeutic use
Cell Communication* / drug effects
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases / metabolism
Heart Diseases / drug therapy,  metabolism*
Nucleotides / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Reg. No./Substance:
0/Cardiotonic Agents; 0/Nucleotides; 148498-78-6/Adrenomedullin; EC 3-Kinase; EC Proteins c-akt; EC Signal-Regulated MAP Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aberrant expression of cytoskeleton proteins in hippocampus from patients with mesial temporal lobe ...
Next Document:  Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinon...