| Adrenomedullin: molecular mechanisms and its role in cardiac disease. | |
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MedLine Citation:
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PMID: 16583314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenomedullin (AM) is a potent, long-lasting vasoactive peptide originally isolated from human pheochromocytoma. Since its discovery, serum and tissue AM expression have been shown to be increased in experimental models and in patients with cardiac hypertrophy, myocardial infarction and end-stage heart failure with several beneficial effects. Considerable evidence exists for a wide range of autocrine, paracrine and endocrine mechanisms for AM which include vasodilatory, anti-apoptotic, angiogenic, anti-fibrotic, natriuretic, diuretic and positive inotropic. Thus, through regulation of body fluid or direct cardiac mechanisms, AM has additive and beneficial effects in the context of heart disease. Notable molecular mechanisms of AM include cyclic adenosine monophosphate, guanosine-3',5'-monophosphate, PI3K/Akt and MAPK-ERK-mediated cascades. Given the endogenous and multifunctional nature of AM, we consider this molecule to have great potential in the treatment of cardiovascular diseases. In agreement, early experimental and preliminary clinical studies suggest that AM is a new and promising therapy for cardiovascular diseases. |
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Authors:
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B Yanagawa; N Nagaya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-04-04 |
Journal Detail:
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Title: Amino acids Volume: 32 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-05 Completed Date: 2007-11-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 157-64 Citation Subset: IM |
Affiliation:
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Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Adrenomedullin / metabolism*, therapeutic use Animals Cardiotonic Agents / metabolism*, therapeutic use Cell Communication* / drug effects Disease Models, Animal Extracellular Signal-Regulated MAP Kinases / metabolism Heart Diseases / drug therapy, metabolism* Humans Nucleotides / metabolism Proto-Oncogene Proteins c-akt / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Nucleotides; 148498-78-6/Adrenomedullin; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases |
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