Document Detail


Adrenomedullin: molecular mechanisms and its role in cardiac disease.
MedLine Citation:
PMID:  16583314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenomedullin (AM) is a potent, long-lasting vasoactive peptide originally isolated from human pheochromocytoma. Since its discovery, serum and tissue AM expression have been shown to be increased in experimental models and in patients with cardiac hypertrophy, myocardial infarction and end-stage heart failure with several beneficial effects. Considerable evidence exists for a wide range of autocrine, paracrine and endocrine mechanisms for AM which include vasodilatory, anti-apoptotic, angiogenic, anti-fibrotic, natriuretic, diuretic and positive inotropic. Thus, through regulation of body fluid or direct cardiac mechanisms, AM has additive and beneficial effects in the context of heart disease. Notable molecular mechanisms of AM include cyclic adenosine monophosphate, guanosine-3',5'-monophosphate, PI3K/Akt and MAPK-ERK-mediated cascades. Given the endogenous and multifunctional nature of AM, we consider this molecule to have great potential in the treatment of cardiovascular diseases. In agreement, early experimental and preliminary clinical studies suggest that AM is a new and promising therapy for cardiovascular diseases.
Authors:
B Yanagawa; N Nagaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-04-04
Journal Detail:
Title:  Amino acids     Volume:  32     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-05     Completed Date:  2007-11-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Affiliation:
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / metabolism
Adrenomedullin / metabolism*,  therapeutic use
Animals
Cardiotonic Agents / metabolism*,  therapeutic use
Cell Communication* / drug effects
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases / metabolism
Heart Diseases / drug therapy,  metabolism*
Humans
Nucleotides / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Nucleotides; 148498-78-6/Adrenomedullin; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases

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