Document Detail

Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure.
MedLine Citation:
PMID:  24107729     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Adrenomodulin (ADM) is a peptide hormone secreted in response to cellular strain such as ischemia and is believed to have a beneficial effect on the cardiovascular system. However, the epidemiological relationships between ADM and measurements of haemodynamics, arteriosclerosis and atherosclerosis are not well established. The aim of this study was to investigate the association between the mid-regional part of pro-ADM (MR-proADM) and brachial pulse pressure (PP), carotid intima-media thickness (cIMT) and carotid atherosclerosis.
METHOD:: This study has a cross-sectional design and includes 4924 individuals (mean age 58 years, 40% men) from Malmö, Sweden, examined between 1991 and 1994. Participants underwent physical examination, measurement of MR-proADM and ultrasound of the carotid arteries.
RESULTS:: There was a positive association between MR-proADM and brachial PP, cIMT as well as a carotid plaque score. The associations were significant after adjustment for age, sex, BMI, hypertension, diabetes, low-density lipoprotein cholesterol and smoking.
CONCLUSION:: ADM is positively associated with brachial PP and both carotid IMT and plaques, suggesting a role for ADM in early haemodynamic pathophysiology related to arteriosclerosis and the atherosclerotic plaque development.
Mikael Gottsäter; Lisa Bellinetto Ford; Gerd Ostling; Magaretha Persson; Peter M Nilsson; Olle Melander
Related Documents :
12889219 - Assessment of kidney involvement.
23408069 - A randomised trial of high and low pressure level settings on an adjustable ventriculop...
24025799 - Differential effects of antihypertensive treatments on apoptosis, oxidative stress, and...
23715049 - Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and caroti...
24588789 - Statistical analysis plan for the 'efficacy of nitric oxide in stroke' (enos) trial.
23054229 - Blood pressure variability in subacute ischemic stroke: a neglected potential therapeut...
15857169 - Normocapnic high-frequency oscillatory ventilation affects differently extrapulmonary a...
1583629 - Doppler echocardiographic assessment of filling and emptying parameters and ambulatory ...
18378859 - Telemedicine home blood pressure measurements and progression of albuminuria in elderly...
Publication Detail:
Journal Detail:
Title:  Journal of hypertension     Volume:  31     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1959-1965     Citation Subset:  -    
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Family history as a predictor of hospitalization for hypertension in Sweden.
Next Document:  Salt intake in children 10-12 years old and its modification by active working practices in a school...