Document Detail

Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz).
MedLine Citation:
PMID:  18054815     Owner:  NLM     Status:  MEDLINE    
Periodic acceleration (pGz) is produced by a platform which moves the supine body repetitively in a headward to footward direction. The imparted motion produces pulsatile shear stress on the vascular endothelium. Pulsatile shear stress on the vascular endothelium has been shown to elicit production of a host of cardioprotective, cytoprotective mediators. The purpose of this study was to ascertain if pGz also enhances production of adrenomedullin (AM) in normal healthy swine. Twelve pigs (weight range 20-30 kg) were anesthetized, intubated and placed on conventional mechanical ventilation. All animals were secured to the motion platform. In one group (pGz) (n=7) was activated for 1h, and monitored for an additional 3h. A control group (CONT) (n=5) served as time control. Arterial blood gases, hemodynamic measurements, and serum for AM, interleukin 4, 6 and thromboxane B(2) (TBXB2) were measured at baseline, immediately after pGz, and 3h after pGz had been discontinued. There was no significant change from baseline value in IL-4, IL-6 or TBXB2. Mean arterial blood pressure decreased in pGz-treated animals from 115+/-10 at baseline to 90+/-8 after 60 min of pGz (p<0.01). AM levels increase from 776+/-176 pg/ml baseline to 1160+/-68 pg/ml immediately after pGz, and remained elevated to 1584+/-160 pg/ml, 3h after pGz (p<0.01 vs. BL). This is the first report of AM-enhanced production using a non-invasive method of increasing pulsatile shear stress on the vascular endothelium. pGz increases production of AM in normal healthy swine. These changes are independent of IL-4, IL-6 or TBXB2 production.
Alfredo Martínez; Jaqueline Arias; Jorge A Bassuk; Heng Wu; Paul Kurlansky; Jose A Adams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-04
Journal Detail:
Title:  Peptides     Volume:  29     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Department of Cellular, Molecular, and Developmental Neurobiology, Instituto Cajal, CSIC, Madrid, Spain.
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MeSH Terms
Acid-Base Equilibrium
Adrenomedullin / blood*
Arteries / physiology
Blood Gas Analysis / methods
Endothelium, Vascular / physiology*
Pulsatile Flow / physiology*
Shear Strength*
Reg. No./Substance:

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