| Adrenomedullin immunoreactivity in the human carotid body. | |
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MedLine Citation:
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PMID: 16154664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied by immunocytochemistry the expression of AM in human carotid bodies, sampled at autopsy from 16 adult subjects (mean age+/-S.D.: 44.3+/-3.4 years) and from six fetuses (mean gestational age+/-S.D.: 167+/-11 days). No AM immunoreactivity was visible in the type II cells of both series. The percentage of immunoreactive type I cells was higher in the adult subjects (32.3+/-7.7%) with respect to the fetuses (11.8+/-2.7%, P < 0.001). Dark cells showed a higher percentage of positive immunoreaction with respect to light cells, both in adult subjects (61.7+/-13.4% versus 19.2+/-5.2%) and in fetuses (25.3+/-4.4% versus 6.2+/-2.0%). AM may play a role in the regulation of chemoreceptor discharge through paracrine releasing action and/or vasodilator effect. The low expression of AM in fetuses may be ascribed to the absence of pulmonary respiration with lack of regulatory role of the carotid body during the prenatal period. |
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Authors:
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Andrea Porzionato; Veronica Macchi; Anna Sandra Belloni; Anna Parenti; Raffaele De Caro |
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Publication Detail:
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Type: Journal Article Date: 2005-09-09 |
Journal Detail:
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Title: Peptides Volume: 27 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-13 Completed Date: 2009-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM |
Affiliation:
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Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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biosynthesis,
immunology*,
metabolism* Adult Apoptosis / physiology Carotid Body / chemistry, cytology, immunology*, metabolism* Cell Hypoxia / physiology Female Fetus / immunology Fluorescent Antibody Technique Humans Immunohistochemistry Male Paracrine Communication / physiology Receptors, Cell Surface / metabolism Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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