| Adrenomedullin and calcitonin gene-related peptide in the rat isolated kidney and in the anaesthetised rat: in vitro and in vivo effects. | |
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MedLine Citation:
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PMID: 7498258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were compared in the rat isolated perfused kidney and in the anaesthetised rat. Adrenomedullin and CGRP both elicited concentration-dependent vasodilator responses from perfused kidneys (adrenomedullin was less potent than CGRP). These responses were blocked by CGRP-(8-37) (1 microM). Adrenomedullin and CGRP elicited dose-dependent hypotension in anaesthetised rats (adrenomedullin was less potent than CGRP). The hypotensive responses to CGRP, but not those to adrenomedullin, were antagonized by CGRP-(8-37) (12 nmol/kg/min). These studies indicate that the in vivo response to adrenomedullin may be mediated through CGRP-(8-37) insensitive receptors. |
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Authors:
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J M Haynes; M E Cooper |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 280 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1996-01-18 Completed Date: 1996-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 91-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Melbourne, Repatriation General Hospital, Heidelberg West, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin Anesthesia Animals Antihypertensive Agents / pharmacology* Calcitonin Gene-Related Peptide / pharmacology* Drug Interactions Hemodynamics / drug effects Kidney / drug effects* Male Peptide Fragments / pharmacology Peptides / pharmacology* Perfusion Rats Rats, Sprague-Dawley Renal Circulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Peptide Fragments; 0/Peptides; 119911-68-1/calcitonin gene-related peptide (8-37); 148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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