Document Detail


Adrenomedullin amidation enzyme activities in hypertensive patients.
MedLine Citation:
PMID:  10770264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenomedullin (AM) is a potent vasodilating peptide secreted from the vasculature of various organs. It is biologically active when its C-terminus is amidated. Recently, an RIA method was developed for measurement of the active form of AM, or mature AM. We here employed this method to investigate the significance of amidation of AM in controlling cardiovascular function. Thirty-six patients under hemodialysis were recruited and divided into hypertensive (n = 25; 157/86 mmHg) and normotensive (n= 11; 116/66 mmHg) groups. Mature AM, immature AM and blood pressure were monitored during hemodialysis in all patients. There was a significant reduction in blood pressure during hemodialysis in both groups, although after hemodialysis blood pressure was still higher in hypertensives than in normotensives (139 +/-14.8/76 +/- 2.5 mmHg vs. 110 +/- 5.1/66.7 +/- 3.1 mmHg). Mature AM before hemodialysis were lower in hypertensives than normotensives and it decreased in both groups. Although mature AM decreased more in normotensives than in hypertensives (-27 +/- 8% vs. -17 +/- 5%), at the end point, its level was still higher in normotensives. The ratio of mature AM/immature AM decreased only in normotensives (-11.4 8.7%), whereas it remained stable in hypertensives (0.2 +/- 5.6%). Both groups showed similar changes in ANP, endothelin, catecholamines, cGMP, and NOx. The low level in mature AM level in hypertensives may have contributed to the higher blood pressure in this group. The attenuation of AM amidation in normotensives indicates that an unspecified amidative enzyme of AM was regulated in order to normalize blood pressure.
Authors:
T Shimosawa; K Kanozawa; R Nagasawa; T Mitarai; K Isoda; K Takahashi; K Ando; Y Tozawa; M Nagase; N Sasaki; M Fujita; K Takano; T Iiri; T Fujita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  23     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Affiliation:
Endocrine and Nephrology Department, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Amides / metabolism*
Female
Humans
Hypertension / blood,  enzymology*,  therapy
Immunoradiometric Assay
Male
Middle Aged
Peptides / blood,  metabolism*
Reference Values
Renal Dialysis
Chemical
Reg. No./Substance:
0/Amides; 0/Peptides; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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