| Adrenocorticotropin-independent Cushing's syndrome in pregnancy related to overexpression of adrenal luteinizing hormone/human chorionic gonadotropin receptors. | |
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MedLine Citation:
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PMID: 19636197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cushing's syndrome during pregnancy is rare, and rather than being of pituitary origin most patients exhibit ACTH-independent adrenal hypercortisolism. In some cases the syndrome has spontaneously resolved post partum, suggesting the presence of a pregnancy-associated stimulatory factor(s). We describe a case with aberrant adrenal LH/hCG receptors in a large adrenal tumor as a possible explanation for cortisol hypersecretion and tumor growth in Cushing s syndrome during pregnancy. A 27-yr-old woman presented with hypertension and diabetes mellitus in early pregnancy. Investigations revealed hypercortisolemia, suppressed ACTH-levels, and a 6.4- cm right adrenal tumor. The tumor was successfully removed by laparoscopy at 26th week of pregnancy. Hypercortisolism and hypertension resolved post-operatively. The tumor displayed higher LH/hCG receptor mRNA and protein positivity than adjacent normal adrenal tissue as examined by in situ hybridization and immunocytochemistry. High physiological levels of hCG, in conjunction with aberrant adrenal LH/hCG receptor overexpression, may have contributed to the development of Cushing's syndrome in pregnancy. |
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Authors:
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E Rask; E Schvarcz; P Hellman; J Hennings; F A Karlsson; C V Rao |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 32 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-07-28 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Orebro University Hospital, 70185 Orebro, Sweden. eva.rask@orebroll.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications,
diagnosis,
metabolism* Adrenocorticotropic Hormone / metabolism* Adult Cushing Syndrome / complications, diagnosis, metabolism* Female Humans Immunoenzyme Techniques Pregnancy Pregnancy Complications, Neoplastic* RNA, Messenger / metabolism Receptors, LH / genetics, metabolism* Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Receptors, LH; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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