| Adrenocorticotropic hormone in the prevention of cisplatin-induced nausea and vomiting. | |
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MedLine Citation:
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PMID: 6321674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind trial to evaluate the antiemetic effects of adrenocorticotropic hormone (ACTH) in patients treated with cisplatin was performed. Thirty-seven adults with advanced cancer who were treated with cisplatin were randomly assigned to receive either synthetic long-acting ACTH (1 mg IM given 24 hours, 12 hours, and immediately preceding the administration of cisplatin) or a placebo given under the same conditions. All of the patients received chlorpromazine (50 mg IM) 30 minutes before cisplatin infusion. Patients receiving ACTH and chlorpromazine had significantly fewer episodes of vomiting (p less than 0.01) and shorter periods of nausea (p less than 0.02) than patients receiving placebo and chlorpromazine. Patients receiving ACTH and chlorpromazine were significantly more comfortable than patients receiving placebo and chlorpromazine. No important side effects were observed. ACTH may be an effective agent in preventing nausea and vomiting induced by cisplatin. |
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Authors:
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N Colbert; V Izrael; J P Lotz; D Stoppa-Lyonnet; J M Vannetzel; F Pene; M Schlienger; A Laugier |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: 1 ISSN: 0732-183X ISO Abbreviation: J. Clin. Oncol. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1984-04-11 Completed Date: 1984-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 635-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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therapeutic use* Adult Aged Antiemetics / therapeutic use* Chlorpromazine / therapeutic use Cisplatin / adverse effects*, therapeutic use Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Nausea / chemically induced, prevention & control* Neoplasms / drug therapy Vomiting / chemically induced, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 15663-27-1/Cisplatin; 50-53-3/Chlorpromazine; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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