Document Detail

Adrenocorticotropic hormone in the prevention of cisplatin-induced nausea and vomiting.
MedLine Citation:
PMID:  6321674     Owner:  NLM     Status:  MEDLINE    
A double-blind trial to evaluate the antiemetic effects of adrenocorticotropic hormone (ACTH) in patients treated with cisplatin was performed. Thirty-seven adults with advanced cancer who were treated with cisplatin were randomly assigned to receive either synthetic long-acting ACTH (1 mg IM given 24 hours, 12 hours, and immediately preceding the administration of cisplatin) or a placebo given under the same conditions. All of the patients received chlorpromazine (50 mg IM) 30 minutes before cisplatin infusion. Patients receiving ACTH and chlorpromazine had significantly fewer episodes of vomiting (p less than 0.01) and shorter periods of nausea (p less than 0.02) than patients receiving placebo and chlorpromazine. Patients receiving ACTH and chlorpromazine were significantly more comfortable than patients receiving placebo and chlorpromazine. No important side effects were observed. ACTH may be an effective agent in preventing nausea and vomiting induced by cisplatin.
N Colbert; V Izrael; J P Lotz; D Stoppa-Lyonnet; J M Vannetzel; F Pene; M Schlienger; A Laugier
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  1     ISSN:  0732-183X     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-04-11     Completed Date:  1984-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / therapeutic use*
Antiemetics / therapeutic use*
Chlorpromazine / therapeutic use
Cisplatin / adverse effects*,  therapeutic use
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Nausea / chemically induced,  prevention & control*
Neoplasms / drug therapy
Vomiting / chemically induced,  prevention & control*
Reg. No./Substance:
0/Antiemetics; 15663-27-1/Cisplatin; 50-53-3/Chlorpromazine; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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