Document Detail

Adrenocortical function and dysfunction in the fetus and neonate.
MedLine Citation:
PMID:  15013472     Owner:  NLM     Status:  MEDLINE    
Under normal circumstances, the fetus is exposed to very low concentrations of cortisol until late in gestation. Perturbations of the intra-uterine environment resulting in fetal exposure to increased cortisol may have consequences not only in infancy, but also into adult life. In the postnatal period, developmental immaturity and/or the effects of critical illness on adrenal function may result in insufficient cortisol production to maintain homeostasis in the face of acute stress or illness, a situation that has been labelled 'relative adrenal insufficiency' in other acutely ill populations. The definition of inadequate adrenal function in the newborn and its possible relationship to adverse outcomes in both premature and term infants are only beginning to be characterized.
Kristi L Watterberg
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  9     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Division of Neonatology, University of New Mexico, Albuquerque, NM 87131-0001, USA.
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MeSH Terms
Adrenal Gland Diseases / embryology*,  physiopathology*
Adrenal Glands / physiology*
Fetus / physiology*
Infant, Newborn / physiology*
Infant, Premature / physiology

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