Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.

Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.

MedLine Citation:	PMID: 18045774 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressure values despite lack of white adipose tissue and its hormones. Furthermore, A-ZIP/F-1 lipoatrophic mice have a significant reduction of adrenal zona glomerulosa, while plasma aldosterone levels and aldosterone synthase mRNA expression remain unchanged. On the other hand, lipoatrophic mice present elevated corticosterone levels but no adrenocortical hyperplasia. Ultrastructural analysis of adrenal gland show significant alterations in adrenocortical cells, with conformational changes of mitochondrial internal membranes and high amounts of liposomes. In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes.

Authors:	Valeria Lamounier-Zepter; Stefan R Bornstein; Jaroslav Kunes; Jozef Zicha; Michal Krsek; Monika Ehrhart-Bornstein; Christian G Ziegler; Andrea Kiessling; Richard H Funk; Martin Haluzik
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Publication Detail:	Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-18
Journal Detail:	Title: Molecular and cellular endocrinology Volume: 280 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2008 Jan
Date Detail:	Created Date: 2007-12-07 Completed Date: 2008-02-14 Revised Date: 2011-07-01
Medline Journal Info:	Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland
Other Details:	Languages: eng Pagination: 39-46 Citation Subset: IM
Affiliation:	Department of Internal Medicine III, University Medical Center, University of Dresden, 01307 Dresden, Germany. valeria.zepter@uniklinikum-gresden.de
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MeSH Terms
Descriptor/Qualifier:	Adipokines / blood Adipose Tissue, White / metabolism, pathology Adrenal Cortex / enzymology, metabolism, ultrasonography Aldosterone / blood Aldosterone Synthase / genetics, metabolism Animals Blood Glucose / metabolism Blood Pressure Corticosterone / blood Diabetes Mellitus, Lipoatrophic / complications, genetics, metabolism, pathology, physiopathology Disease Models, Animal Hypertension / genetics, metabolism, pathology, physiopathology Insulin / blood Lipids / blood Male Mice Mice, Transgenic Microscopy, Electron Mitochondria / metabolism, ultrastructure Mitochondrial Membranes / metabolism, ultrastructure RNA, Messenger / metabolism Transcription Factors / genetics, metabolism* Zona Glomerulosa / metabolism
Chemical
Reg. No./Substance:	0/Adipokines; 0/Blood Glucose; 0/Lipids; 0/RNA, Messenger; 0/Tg(AZIP-F)1Vsn protein, mouse; 0/Transcription Factors; 11061-68-0/Insulin; 50-22-6/Corticosterone; 52-39-1/Aldosterone; EC 1.14.15.4/Aldosterone Synthase

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