Document Detail


Adrenocortical carcinoma and pregnancy: clinical and biological features and prognosis.
MedLine Citation:
PMID:  20699382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Adrenocortical carcinoma (ACC) is a rare, severe disease. Pregnancy-associated ACC has rarely been reported. We wished to evaluate the characteristics and prognosis of ACC diagnosed in patients during pregnancy or in the postpartum period, comparing them with those for ACC diagnosed in nonpregnant women. DESIGN: Clinical presentation, hormonal secretion, staging, survival, and obstetric data are reported. Patients were included between 1963 and 2007. Mean follow-up was 48 months. PATIENTS AND METHODS: This is a retrospective cohort study carried out at a referral center. All female patients aged 16-49 years diagnosed with ACC during the observation period were included (n=110). Twelve of these women were pregnant or in the first 6 months after delivery. Hormonal secretion, staging, obstetric data, and survival were analyzed. For the survival analysis, pregnant patients were compared with a subgroup of nonpregnant women matched for age, stage, and year of diagnosis (1 pregnant patient/2 controls). RESULTS: Adrenocortical tumors diagnosed during pregnancy or in the postpartum period tend to be more often cortisol-secreting tumors (P=0.06) and to be discovered at a more advanced stage than those in nonpregnant women, although the differences were not significant. Fetal outcome was poor. Overall survival of the mother was worse than that of matched controls (hazard ratio of death: 3.98, confidence interval=1.34-11.85, P=0.013). CONCLUSION: ACC diagnosed during pregnancy or in the postpartum period is associated with a poor fetal outcome and a poorer prognosis than ACC diagnosed in nonpregnant women.
Authors:
Gwenaëlle Abiven-Lepage; Joël Coste; Frédérique Tissier; Lionel Groussin; Line Billaud; Bertrand Dousset; François Goffinet; Xavier Bertagna; Jérôme Bertherat; Marie-Laure Raffin-Sanson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-10
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  163     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-800     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Cortex Neoplasms / diagnosis*,  physiopathology,  surgery
Adrenocortical Carcinoma / diagnosis*,  physiopathology,  surgery
Adult
Cohort Studies
Female
Follow-Up Studies
Humans
Infant, Newborn
Middle Aged
Postpartum Period / physiology
Pregnancy
Pregnancy Complications, Neoplastic / diagnosis*,  physiopathology,  surgery
Premature Birth / diagnosis,  etiology
Prognosis
Retrospective Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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