Document Detail


Adrenocortical and adipose responses to high-altitude-induced, long-term hypoxia in the ovine fetus.
MedLine Citation:
PMID:  22666594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By late gestation, the maturing hypothalamo-pituitary-adrenal (HPA) axis aids the fetus in responding to stress. Hypoxia represents a significant threat to the fetus accompanying situations such as preeclampsia, smoking, high altitude, and preterm labor. We developed a model of high-altitude (3,820 m), long-term hypoxia (LTH) in pregnant sheep. We describe the impact of LTH on the fetal HPA axis at the level of the hypothalamic paraventricular nucleus (PVN), anterior pituitary corticotrope, and adrenal cortex. At the PVN and anterior pituitary, the responses to LTH are consistent with hypoxia being a potent activator of the HPA axis and potentially maladaptive, while the adrenocortical response to LTH appears to be primarily adaptive. We discuss mechanisms involved in the delicate balance between these seemingly opposing responses that preserve the normal ontogenic rise in fetal plasma cortisol essential for organ maturation and in this species, birth. Further, we examine the response to, and ramifications of, an acute secondary stressor in the LTH fetus. We provide an integrative model on the potential role of adipose in modulating these responses to LTH. Integration of these adaptive responses to LTH plays a key role in promoting normal fetal growth and development under conditions of a chronic stress.
Authors:
Dean A Myers; Charles A Ducsay
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-14
Journal Detail:
Title:  Journal of pregnancy     Volume:  2012     ISSN:  2090-2735     ISO Abbreviation:  J Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-05     Completed Date:  2013-06-03     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101553823     Medline TA:  J Pregnancy     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  681306     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. dean-myers@ouhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adipose Tissue / embryology*,  metabolism
Altitude*
Animals
Biological Markers / metabolism
Female
Fetal Hypoxia / etiology,  metabolism*
Hydrocortisone / metabolism
Hypothalamo-Hypophyseal System / embryology*,  metabolism,  physiology
Leptin / metabolism
Nitric Oxide / metabolism
Pituitary-Adrenal System / embryology*,  metabolism,  physiology
Pregnancy
Sheep
Grant Support
ID/Acronym/Agency:
P01-HD31226/HD/NICHD NIH HHS; R01 HD051951/HD/NICHD NIH HHS; R01-HD33147/HD/NICHD NIH HHS; R01-HD51951/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Leptin; 10102-43-9/Nitric Oxide; 50-23-7/Hydrocortisone
Comments/Corrections

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