| Adrenocortical and adipose responses to high-altitude-induced, long-term hypoxia in the ovine fetus. | |
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MedLine Citation:
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PMID: 22666594 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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By late gestation, the maturing hypothalamo-pituitary-adrenal (HPA) axis aids the fetus in responding to stress. Hypoxia represents a significant threat to the fetus accompanying situations such as preeclampsia, smoking, high altitude, and preterm labor. We developed a model of high-altitude (3,820 m), long-term hypoxia (LTH) in pregnant sheep. We describe the impact of LTH on the fetal HPA axis at the level of the hypothalamic paraventricular nucleus (PVN), anterior pituitary corticotrope, and adrenal cortex. At the PVN and anterior pituitary, the responses to LTH are consistent with hypoxia being a potent activator of the HPA axis and potentially maladaptive, while the adrenocortical response to LTH appears to be primarily adaptive. We discuss mechanisms involved in the delicate balance between these seemingly opposing responses that preserve the normal ontogenic rise in fetal plasma cortisol essential for organ maturation and in this species, birth. Further, we examine the response to, and ramifications of, an acute secondary stressor in the LTH fetus. We provide an integrative model on the potential role of adipose in modulating these responses to LTH. Integration of these adaptive responses to LTH plays a key role in promoting normal fetal growth and development under conditions of a chronic stress. |
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Authors:
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Dean A Myers; Charles A Ducsay |
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Publication Detail:
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Type: Journal Article Date: 2012-05-14 |
Journal Detail:
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Title: Journal of pregnancy Volume: 2012 ISSN: 2090-2735 ISO Abbreviation: J Pregnancy Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-05 Completed Date: 2012-08-23 Revised Date: 2013-02-27 |
Medline Journal Info:
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Nlm Unique ID: 101553823 Medline TA: J Pregnancy Country: Egypt |
Other Details:
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Languages: eng Pagination: 681306 Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HD051951/HD/NICHD NIH HHS |
| Comments/Corrections | |
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