| Adrenoceptor-mediated secretion across the rat colonic epithelium. | |
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MedLine Citation:
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PMID: 10973627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Norepinephrine evoked a biphasic change in short-circuit current (Isc) across the proximal and distal colon of the rat. The (1) phase of the current response consisted of a transient increase, which was followed by a long-lasting decrease during the (2) phase. The (1) phase, which is assumed to represent Cl(-) secretion, was resistant against classical adrenoceptor antagonists, but was inhibited by the beta(3)-adrenoceptor antagonist 3-(2-ethylpenoxy)-1-[(1S-1,2,3, 4-tetrahydronaphth-1-ylaminol-(2S)-propranol oxalate (SR 59230A) in the proximal colon and by the non-selective beta-adrenoceptor antagonist bupranolol in both colonic segments. Vice versa, the increase in Isc was mimicked by the beta(3)-adrenoceptor agonist, (R*, R*)-(+/-)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]pheno xyacetic acid (BRL 37344). The (2) phase of the norepinephrine-induced Isc, which is assumed to represent K(+) secretion, was inhibited by yohimbine in the proximal colon, suggesting the mediation by alpha(2)-adrenoceptors, whereas in the distal colon, both alpha- and beta-adrenoceptors are involved, as shown by the sensitivity against, e.g. phentolamine and propranolol. These adrenoceptors seem to be located - at least in part - at extraepithelial sites because the (1) phase of the norepinephrine response was sensitive to indomethacin, and the (2) phase, both to indomethacin and tetrodotoxin. |
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Authors:
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G Schultheiss; M Diener |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 403 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-07 Completed Date: 2000-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 251-8 Citation Subset: IM |
Affiliation:
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Institut für Veterinär-Physiologie, Justus-Liebig-Universität Giessen, Frankfurter Str. 100, D-35392, Giessen, Germany. gerhard.schultheiss@vetmed.un-giessen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colon / secretion* Intestinal Mucosa / drug effects, metabolism, secretion* Nerve Endings / drug effects, metabolism Norepinephrine / metabolism, pharmacology Rats Rats, Wistar Receptors, Adrenergic / drug effects* Receptors, Adrenergic, beta / drug effects Receptors, Adrenergic, beta-3 / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 0/Receptors, Adrenergic, beta-3; 51-41-2/Norepinephrine |
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