Document Detail

Adrenergic vasoconstriction of the goat middle cerebral artery.
MedLine Citation:
PMID:  210678     Owner:  NLM     Status:  MEDLINE    
The effects of field electrical stimulation on the contractile response of the isolated middle cerebral artery of the goat were evaluated before and after the use of experimental procedures designed to test the adrenergic component involved. Supramaximal stimuli produced frequency-dependent increases in tension. This response was significantly reduced by phentolamine (10(-6) M), tetrodotoxin (3 X 10(-6) M), and bretylium (5 X 10(-5) M), but not by cocaine (10(-6) M). Arterial segments from goats pretreated with reserpine and from goats in which both superior cervical sympathetic ganglia had been removed 12 days prior to the experiment also showed a significant decrease in the contraction elicited by electrical stimulation. The norepinephrine concentration of the arteries of the circle of Willis from control goats was 2.10 microgram per gram of tissue. Reserpine or gangliectomy reduced the catecholamine content to undetectable levels. It is likely that a major part of the contractile response of cerebral arteries to electrical stimulation is due to release of endogenous norepinephrine which in turn activates the alpha-adrenergic receptors.
M V Conde; J Marín; M Salaíces; E J Marco; B Gómez; S Lluch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  235     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H131-5     Citation Subset:  IM    
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MeSH Terms
Bretylium Tosylate / pharmacology
Cerebral Arteries / physiology*
Cocaine / pharmacology
Electric Stimulation
Muscle, Smooth / physiology
Norepinephrine / physiology
Phentolamine / pharmacology
Receptors, Adrenergic / physiology*
Receptors, Adrenergic, alpha / physiology*
Regional Blood Flow
Reserpine / pharmacology
Tetrodotoxin / pharmacology
Vasoconstriction* / drug effects
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 4368-28-9/Tetrodotoxin; 50-36-2/Cocaine; 50-55-5/Reserpine; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 61-75-6/Bretylium Tosylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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