Document Detail

Adrenergic vasoconstriction as a cause of inadequate hypotensive response to beta-adrenergic blockade.
MedLine Citation:
PMID:  6138310     Owner:  NLM     Status:  MEDLINE    
This overview is concerned with the causes of nonresponsiveness to the hypotensive action of beta-adrenergic blocking drugs. The overall hemodynamic response, i.e., a secondary decrease in peripheral vascular resistance, is unrelated to the primary decrease in cardiac output. The reduction in vascular resistance may be triggered by mechanisms residing in the central nervous system, the arterial baroreceptor area, or the prejunctional beta-receptor. None of these mechanisms seem to be entirely responsible. Studies in responders vs nonresponders tend to equate nonresponsiveness with alpha-adrenoceptor-mediated vasoconstriction. Although circulating catecholamines are relatively poor indices of sympathetic activity, studies focusing on the renal-neural area appear to show clearly differential profiles between responders and nonresponders. Such findings, in relation to experimental data on the renal nerves as selective neural amplifiers, may provide a renewed interpretation of the centrally mediated hypotensive mechanism of beta-adrenergic blockade.
W H Birkenhäger; P W DeLeeuw
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Sep-Oct
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III31-5     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology,  therapeutic use*
Blood Pressure / drug effects*
Cardiac Output / drug effects
Catecholamines / blood
Kidney / blood supply,  drug effects*
Pressoreceptors / drug effects
Regional Blood Flow
Renin / blood
Vascular Resistance / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Catecholamines; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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