Document Detail

Adrenergic responsiveness of adipose tissue lipolysis in autonomic failure.
MedLine Citation:
PMID:  15095049     Owner:  NLM     Status:  MEDLINE    
The sympathetic nervous system mobilizes lipids from adipose tissue through stimulation of beta-adrenergic receptors. The increase in lipid supply augments lipid oxidation. Patients with autonomic failure provide a unique opportunity to further elucidate the role of the adrenergic system in adipose tissue metabolism. In 4 patients with severe pure autonomic failure (PAF), in 3 multiple system atrophy patients (MSA), and in 16 healthy young controls, we inserted a microdialysis catheter in abdominal adipose tissue. The catheter was perfused with incremental concentrations of the nonselective beta-adrenoreceptor agonist isoproterenol. Dialysate glucose, lactate, and glycerol were measured to assess glucose supply, glycolysis, and lipolysis, respectively. Basal dialysate glycerol concentrations were 84 +/- 28 microM in PAF and 130 +/- 64 microM in MSA patients. The increase in dialysate glycerol with isoproterenol was identical in PAF and in MSA patients. We found an almost complete overlap in dialysate glycerol concentrations during isoproterenol stimulation between PAF and MSA patients and healthy young control subjects. Our findings suggest that adipose tissue metabolism is remarkably well preserved in patients with chronic sympathetic denervation, both at rest and during local adrenergic stimulation. We propose that beta-adrenoreceptor upregulation is compensated by a desensitization of post receptor mechanisms or by an upregulation of antilipolytic pathways.
Jens Jordan; Raffaello Furlan; Jens Tank; Simonetta Furlan; Friedrich C Luft; Michael Boschmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  14     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  80-3     Citation Subset:  IM    
Medical Faculty of the Charité, Franz Volhard Clinical Research Center, Helios Klinikum and Max Delbrück Center, Berlin, Germany.
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MeSH Terms
Adipose Tissue / innervation,  metabolism*
Aged, 80 and over
Autonomic Nervous System Diseases / metabolism*
Lipolysis / physiology*
Middle Aged
Norepinephrine / blood
Receptors, Adrenergic, beta / metabolism*
Sympathetic Nervous System / metabolism
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine

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