| Adrenergic regulation of renin secretion and renal hemodynamics during deliberate hypotension in humans. | |
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MedLine Citation:
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PMID: 8238548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the relative contributions of neural and nonneural stimuli of renin secretion, the effects of an alpha 1-agonist, phenylephrine (Phe), or a beta-agonist, epinephrine (Epi), on plasma renin activity (PRA), renal blood flow (RBF), and glomerular filtration rate (GFR) were compared during sympathetic blockade with epidural hypotensive anesthesia [mean arterial blood pressure (MAP) = 60 and 50 mmHg]. Controls (NaCl) received saline alone to maintain MAP at 50 mmHg. Epi increased PRA (ng.ml-1.h-1) from 0.9 +/- 0.6 to 3.0 +/- 1.5 at 60 mmHg MAP and 4.7 +/- 1.8 at 50 mmHg MAP, with associated decreases in RBF (-33 and -60%, respectively) and GFR (-27 and -53%, respectively). During hypotension with Phe and NaCl, PRA and RBF were unchanged from baseline but GFR decreased. Urinary Na secretion decreased comparably in all three groups. In conclusion, during sympathetic blockade with epidural anesthesia, marked reductions in both renal perfusion pressure and distal nephron Na delivery were insufficient to increase renin secretion. beta-Adrenergic stimulation (e.g., Epi) was required to increase PRA. Epi decreased RBF suggesting an angiotensin II-mediated effect. |
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Authors:
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V M Zayas; J D Blumenfeld; B Bading; M McDonald; G D James; Y F Lin; N E Sharrock; J E Sealey; J H Laragh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 265 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-12-20 Completed Date: 1993-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: F686-92 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Hospital for Special Surgery, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Epidural Blood Pressure / drug effects Cardiac Output / drug effects Diastole / drug effects Epinephrine / pharmacology* Glomerular Filtration Rate / drug effects Heart Rate / drug effects Hemodynamics / drug effects* Hip Prosthesis Humans Hypotension / physiopathology* Kidney / blood supply, drug effects, physiology* Phenylephrine / pharmacology* Receptors, Adrenergic / drug effects, physiology Renal Circulation / drug effects*, physiology Renin / blood, secretion* Sodium / urine Systole / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-18323/HL/NHLBI NIH HHS; RR-00047/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 51-43-4/Epinephrine; 59-42-7/Phenylephrine; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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