Document Detail


Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study.
MedLine Citation:
PMID:  16907703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between polymorphisms in the beta1, beta2 and alpha2B adrenergic receptor (ADR) genes (ADRB1, ADRB2 and ADRA2B) and resting heart rate was examined in white and African-American participants of the HyperGEN Study. All analyses were adjusted for age, sex, body mass index, alcohol use, smoking status and daily exercise within strata of race, hypertension status and beta-blocker use. The Ser49Gly polymorphism of the beta1 ADR was associated with resting heart rate in hypertensive African-Americans and hypertensive whites taking beta-blockers, with carriers of the Gly allele having a higher mean resting heart rate by 2.7 and 4.4 beats per minute (bpm), respectively. The Arg389Gly polymorphism of the beta1 ADR was associated with lower heart rate in the normotensive African-American sample. A beta1 haplotype (Ser49Gly-Arg389Gly) was modestly associated with resting heart rate in the hypertensive African-Americans. The alpha2B C/A polymorphism was associated with heart rate in hypertensive whites, and both whites and African-Americans taking beta-blockers, with carriers of the A allele having a higher mean resting heart rate. In summary, each of the ADR gene polymorphisms was associated with heart rate in at least one stratum studied, but there was no consistent association from which one would infer a large genetic contribution to heart rate.
Authors:
J B Wilk; R H Myers; J S Pankow; S C Hunt; M F Leppert; B I Freedman; M A Province; R C Ellison
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Publication Detail:
Type:  Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of human genetics     Volume:  70     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-15     Completed Date:  2006-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  566-73     Citation Subset:  IM    
Affiliation:
Boston University School of Medicine, MA 02118, USA. jwilk@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology
Adult
African Americans
European Continental Ancestry Group
Female
Heart Rate / drug effects,  genetics*
Humans
Hypertension / epidemiology,  ethnology,  genetics
Male
Polymorphism, Genetic / genetics*
Receptors, Adrenergic / genetics*
Grant Support
ID/Acronym/Agency:
U10 HL54471/HL/NHLBI NIH HHS; U10 HL54472/HL/NHLBI NIH HHS; U10 HL54473/HL/NHLBI NIH HHS; U10 HL54495/HL/NHLBI NIH HHS; U10 HL54496/HL/NHLBI NIH HHS; U10 HL54497/HL/NHLBI NIH HHS; U10 HL54509/HL/NHLBI NIH HHS; U10 HL54515/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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