Document Detail

Adrenergic receptor hyperactivity--a cause for pseudopheochromocytoma?
MedLine Citation:
PMID:  3031435     Owner:  NLM     Status:  MEDLINE    
Two patients with classical signs and symptoms of pheochromocytoma, are described. In these two patients the 24-hr urinary excretion of dopamine, norepinephrine, epinephrine and their metabolites were normal or low, both in basal states or after attacks (spontaneous or provoked). However, the 24-hr urinary excretion of cyclic AMP was exceedingly high in one patient (13000 nmol/gm creatinine), and elevated in the second (5920 nmol/gm creatinine). Both patients were benefited by treatment with a combination of alpha and beta adrenergic blocking drugs. The first patient, after stopping treatment, developed hypertensive crisis and died. Post-mortem examination did not detect a pheochromocytoma or any other abnormality which could explain the excessively elevated cyclic AMP. In the second patient, extensive X-ray and CT examinations were negative for pheochromocytoma. A hypothesis is developed linking the symptoms and biochemical findings of both patients to an abnormality of the adrenergic receptor.
I Blum; R Weinstein; M Sztern; M Lahav
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  22     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-29     Completed Date:  1987-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / diagnosis*
Catecholamines / urine
Cyclic AMP / urine
Diagnostic Errors
Drug Therapy, Combination
Middle Aged
Phenoxybenzamine / therapeutic use
Pheochromocytoma / diagnosis*
Propranolol / therapeutic use
Receptors, Adrenergic / physiology*
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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