| Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway. | |
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MedLine Citation:
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PMID: 21472269 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Calcineurin and its downstream effectors nuclear factor of activated T-cells 3 (NFAT3) and zinc finger-containing transcription factor (GATA4) have been implicated in the development of cardiac hypertrophy. The aims of the present study were to investigate alterations in the calcineurin/NFAT3/GATA4 pathway in pressure-overload hypertrophy, and to determine whether adrenergic receptor blockade affects this signaling pathway. In aorta-banded rats compared with sham-operated rats, a significant increase in the phosphorylation levels of calcineurin and GATA4 was observed (both p<0.05), while the NFAT3 phosphorylation level was markedly decreased (p<0.05). Oral administration of either the non-selective β blocker/α-1 blocker carvedilol or the selective β-1 blocker metoprolol, but not the selective α-1 blocker terazosin, significantly suppressed the activated calcineurin/NFAT3/GATA4 pathway (all p<0.05) in addition to inducing a regression of cardiac hypertrophy. Pressure overload-induced up-regulation of c-myc was markedly attenuated by treatment with either carvedilol or metoprolol (both p<0.05). The present findings may expand our understanding of the correlation between sympathetic activity and the calcineurin/NFAT3/GATA4 pathway, and highlight these signal transducers as effective targets in the management of pressure overload-induced cardiac hypertrophy. |
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Authors:
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Dachun Yang; Shuangtao Ma; Yan Tan; De Li; Bing Tang; Jinsong Chen; Xiaohua Su; Gang Li; Xin Zhang; Yongjian Yang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular medicine reports Volume: 3 ISSN: 1791-3004 ISO Abbreviation: Mol Med Rep Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2012-10-02 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 497-501 Citation Subset: - |
Affiliation:
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Department of Cardiology, General Hospital of PLA Chengdu Military Area Command, Chengdu, Sichuan 610083, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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