Document Detail

Adrenergic modulation of the blood neutrophilia induced by platelet activating factor in rats.
MedLine Citation:
PMID:  7913046     Owner:  NLM     Status:  MEDLINE    
The involvement of catecholamines in blood neutrophilia observed after administration of platelet activating factor (PAF) to rats was studied. Intravenous (i.v.) injection of PAF (4 micrograms/kg) into naive rats more than doubled the number of neutrophils after 1 h. In contrast, PAF failed to induce neutrophilia in both adrenalectomized rats and those which had their catecholamine stores depleted by reserpine. PAF-induced neutrophilia was not inhibited by the selective antagonism of alpha 1- and alpha 2-adrenoceptors with prazosin and yohimbine, respectively. However, pretreatment with the beta-adrenoceptor antagonist, propranolol, significantly inhibited the phenomenon. Increase in the blood neutrophil counts was also achieved following the i.v. injection of the beta-agonist, salbutamol (1 mg/kg, i.v.). This response was clearly sensitive to propranolol but was not modified in rats submitted to adrenalectomy or reserpine pretreatment. The results suggest that the blood neutrophilia induced by the i.v. administration of PAF in rats is dependent on the stimulation of beta-adrenoceptors by catecholamines released from adrenal glands.
S P Altenburg; P T Bozza; M A Martins; E V Tibiriçá; P M Silva; R S Cordeiro; H C Castro-Faria-Neto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  256     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-10     Completed Date:  1994-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Bone Marrow / drug effects
Bone Marrow Cells
Leukocyte Count / drug effects
Neutrophils / drug effects*
Platelet Activating Factor / pharmacology*
Rats, Wistar
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors
Receptors, Adrenergic, alpha-2 / antagonists & inhibitors
Reserpine / pharmacology
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Platelet Activating Factor; 0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, alpha-2; 50-55-5/Reserpine

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