Document Detail


Adrenergic innervation of forebrain neurons that project to the paraventricular thalamic nucleus in the rat.
MedLine Citation:
PMID:  8593574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paraventricular thalamic nucleus (PVT) lies in a pivotal position between the sensorium and a neural network involved in viscerolimbic integration. The aim of this study was to identify pathways used by adrenergic afferents to influence the outflow of the PVT. Potential disynaptic adrenergic projections to the PVT were investigated in chloral hydrate-anesthetized male Sprague-Dawley rats. PVT afferents were retrogradely labeled with cholera toxin B subunit on tissues processed with phenylethanolamine N-methyltransferase (PNMT) immunohistochemistry for displaying putative adrenergic innervation. In several regions of subcortical forebrain, PNMT-immunoreactive terminal-like varicosities were found to be closely associated with the soma and proximal dendritic segments of neurons retrogradely labeled from the PVT. These cell groups formed two topographically organized projection systems. The lateral telencephalic system was composed of a cell continuum formed by the central nucleus of amygdala, sublenticular substantia innominata and bed nucleus of the stria terminalis. The medial diencephalic system included the lateral hypothalamic area, perifornical nucleus, dorsomedial and periventricular hypothalamic nuclei. Adrenergic neurons in the medulla oblongata may modulate the activity of midline thalamic circuit neurons implicated in behavior.
Authors:
K Otake; D A Ruggiero; Y Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  697     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-04-11     Completed Date:  1996-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / physiology
Animals
Cerebral Ventricles
Cholera Toxin
Immunohistochemistry
Male
Neural Pathways*
Neurons / cytology*
Peptide Fragments
Phenylethanolamine N-Methyltransferase / metabolism
Prosencephalon / cytology*
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / cytology*,  physiology
Thalamic Nuclei / cytology*
Grant Support
ID/Acronym/Agency:
HL18974/HL/NHLBI NIH HHS; NS28200/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 9012-63-9/Cholera Toxin; EC 2.1.1.28/Phenylethanolamine N-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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