Document Detail

Adrenergic hypersensitivity after beta-blocker withdrawal.
MedLine Citation:
PMID:  6114739     Owner:  NLM     Status:  MEDLINE    
We investigated the possibility of a rebound increase in sympathetic response after stopping beta-blocker treatment by measuring heart rate under conditions of increased sympathetic drive, as provided by standing with vasodilatation, or the Valsalva manoeuvure. Significant rebound increases in heart rate were observed after stopping propranolol given for one or more weeks but not when given for only four days. The amplitude of the rebound heart rate relative to the control heart rate off beta-blockers was similar after propranolol, atenolol, oxprenolol, or acebutolol, and in hyperthyroid subjects.
P J Ross; M J Lewis; D J Sheridan; A H Henderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British heart journal     Volume:  45     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  637-42     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*,  therapeutic use
Angina Pectoris / drug therapy,  physiopathology
Heart Rate / drug effects
Hyperthyroidism / drug therapy,  physiopathology
Nitroglycerin / pharmacology
Substance Withdrawal Syndrome / physiopathology*
Sympathetic Nervous System / physiopathology*
Valsalva Maneuver
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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