Document Detail

Adrenergic control of the force-frequency relation.
MedLine Citation:
PMID:  7554218     Owner:  NLM     Status:  MEDLINE    
This article briefly reviews recent experimental studies which show that beta-adrenergic receptor stimulation produces an important enhancement of the force-frequency relation on myocardial contractility. The basic property of the force-frequency effect to progressively enhance myocardial contractility as heart rate increases is augmented at each level of increasing adrenergic stimulation. This newly described intrinsic mechanism for the control of cardiac inotropic state, graded beta-adrenergic amplification of the force-frequency relation, is strongly manifested during normal exercise and infusion of a beta-adrenergic agonist at rest, and it influences both systolic and diastolic ventricular function. Significant impairment of adrenergic amplification of the force-frequency relation is observed in experimental heart failure and could contribute to impaired cardiac function during stress or exercise in this setting.
J Ross; T Miura; M Kambayashi; G P Eising; K H Ryu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Circulation     Volume:  92     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-14     Completed Date:  1995-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2327-32     Citation Subset:  AIM; IM    
Department of Medicine, University of California, San Diego, La Jolla 92093-0613, USA.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Diastole / physiology
Exercise / physiology*
Heart Failure / physiopathology
Heart Rate / physiology
Myocardial Contraction / physiology*
Receptors, Adrenergic, beta / physiology*
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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