| Adrenergic control of the force-frequency relation. | |
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MedLine Citation:
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PMID: 7554218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article briefly reviews recent experimental studies which show that beta-adrenergic receptor stimulation produces an important enhancement of the force-frequency relation on myocardial contractility. The basic property of the force-frequency effect to progressively enhance myocardial contractility as heart rate increases is augmented at each level of increasing adrenergic stimulation. This newly described intrinsic mechanism for the control of cardiac inotropic state, graded beta-adrenergic amplification of the force-frequency relation, is strongly manifested during normal exercise and infusion of a beta-adrenergic agonist at rest, and it influences both systolic and diastolic ventricular function. Significant impairment of adrenergic amplification of the force-frequency relation is observed in experimental heart failure and could contribute to impaired cardiac function during stress or exercise in this setting. |
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Authors:
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J Ross; T Miura; M Kambayashi; G P Eising; K H Ryu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Circulation Volume: 92 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-14 Completed Date: 1995-11-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2327-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of California, San Diego, La Jolla 92093-0613, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology Animals Diastole / physiology Exercise / physiology* Heart Failure / physiopathology Heart Rate / physiology Humans Myocardial Contraction / physiology* Receptors, Adrenergic, beta / physiology* Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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