| Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. | |
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MedLine Citation:
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PMID: 2153706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three settings: congestive heart failure, dynamic exercise, and beta-adrenergic agonist treatment. We compared the number and subset distribution of circulating lymphocytes in 36 patients with congestive heart failure and 31 age-matched control subjects. The number of circulating lymphocytes was lower in heart failure than in control. This was due to a reduction in Tsuppressor/cytotoxic and natural killer cells without significant alteration of Thelper cells. The extent of the alteration was similar in patients with idiopathic and ischemic heart failure, but the reduction was more pronounced in patients with New York Heart Association class III-IV than in class I-II. The plasma catecholamine elevation in heart failure was also independent of etiology but more pronounced in the more severely ill patients. We also assessed lymphocyte subsets after acute stimulation of sympathetic activity by dynamic exercise and after treatment with the beta-adrenergic agonist terbutaline. Dynamic exercise until exhaustion increased the number of circulating lymphocytes in healthy controls and heart failure patients in a subset-selective manner. By contrast, a 7-d treatment with terbutaline caused a reduction in the circulating number of lymphocytes in some subsets that was identical to that seen in heart failure patients. We conclude that prolonged sympathetic activity reduces the number of circulating lymphocytes by a beta-adrenergic mechanism. Such alterations might be involved in the pathophysiology of heart failure and other disease states involving increased activity of the sympathetic nervous system. |
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Authors:
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A S Maisel; K U Knowlton; P Fowler; A Rearden; M G Ziegler; H J Motulsky; P A Insel; M C Michel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 85 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-03-15 Completed Date: 1990-03-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 462-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of California, San Diego 92037. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Heart Failure / blood* Humans Leukocyte Count Lymphocytes / drug effects, physiology* Male Middle Aged Physical Exertion* Receptors, Adrenergic, beta / drug effects Sympathetic Nervous System / physiology* Terbutaline / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 23031-25-6/Terbutaline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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