Document Detail


Adrenergic and cholinergic receptors in isolated non-pigmented ciliary epithelial cells.
MedLine Citation:
PMID:  3893898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methods were developed to isolate non-pigmented ciliary epithelium from bovine eyes (BCBE) free from other cell types in the ciliary process. Once background binding due to pigment was minimized, it was possible to assay specific beta adrenergic receptors in these preparations. The BCBE beta adrenergic receptors showed appropriate stereospecificity and an order of binding affinities compatible with a beta 2 adrenergic selectivity. Interestingly, specific high affinity muscarinic cholinergic receptors were detected in both BCBE and primate non-pigmented ciliary epithelium. These muscarinic receptors showed an appropriate affinity and selectivity for agonists and antagonists. Further evaluations of the receptors and responses of non-pigmented ciliary epithelial cells may prove useful in understanding the effects of adrenergic and cholinergic agents on aqueous humor inflow.
Authors:
J R Polansky; D Zlock; A Brasier; E Bloom
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  4     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding, Competitive
Cattle
Ciliary Body / cytology,  metabolism*,  ultrastructure
Epithelial Cells
Epithelium / metabolism,  ultrastructure
Microscopy, Phase-Contrast
Receptors, Adrenergic / metabolism*
Receptors, Cholinergic / metabolism*
Receptors, Muscarinic / metabolism
Sympathomimetics / metabolism
Grant Support
ID/Acronym/Agency:
EY-02162/EY/NEI NIH HHS; EY-03980/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Cholinergic; 0/Receptors, Muscarinic; 0/Sympathomimetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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