| Adrenergic and cholinergic receptors in isolated non-pigmented ciliary epithelial cells. | |
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MedLine Citation:
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PMID: 3893898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methods were developed to isolate non-pigmented ciliary epithelium from bovine eyes (BCBE) free from other cell types in the ciliary process. Once background binding due to pigment was minimized, it was possible to assay specific beta adrenergic receptors in these preparations. The BCBE beta adrenergic receptors showed appropriate stereospecificity and an order of binding affinities compatible with a beta 2 adrenergic selectivity. Interestingly, specific high affinity muscarinic cholinergic receptors were detected in both BCBE and primate non-pigmented ciliary epithelium. These muscarinic receptors showed an appropriate affinity and selectivity for agonists and antagonists. Further evaluations of the receptors and responses of non-pigmented ciliary epithelial cells may prove useful in understanding the effects of adrenergic and cholinergic agents on aqueous humor inflow. |
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Authors:
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J R Polansky; D Zlock; A Brasier; E Bloom |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Current eye research Volume: 4 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-09-19 Completed Date: 1985-09-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 517-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding, Competitive Cattle Ciliary Body / cytology, metabolism*, ultrastructure Epithelial Cells Epithelium / metabolism, ultrastructure Microscopy, Phase-Contrast Receptors, Adrenergic / metabolism* Receptors, Cholinergic / metabolism* Receptors, Muscarinic / metabolism Sympathomimetics / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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EY-02162/EY/NEI NIH HHS; EY-03980/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Cholinergic; 0/Receptors, Muscarinic; 0/Sympathomimetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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