Document Detail

Adrenergic-cholinergic balance and the treatment of affective disorders.
MedLine Citation:
PMID:  6684317     Owner:  NLM     Status:  MEDLINE    
Centrally acting cholinomimetic drugs cause anergia, behavioral inhibition and depression. Centrally acting cholinomimetic drugs have antimanic properties. Combinations of acetylcholine precursors and centrally active cholinomimetic agents may cause augmented muscarinic effects, as may a combination of an antiadrenergic and cholinomimetic drugs. Centrally active anticholinergic agents may exert antidepressant effects. Affective disorder patients may show hyperreactivity to cholinomimetic agents, a phenomena which may have diagnostic significance.
D S Janowsky; S C Risch; J C Gillin
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  7     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  297-307     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / metabolism
Bipolar Disorder / drug therapy*
Brain / drug effects
Depressive Disorder / drug therapy*
Lithium / therapeutic use
Parasympatholytics / therapeutic use
Parasympathomimetics / therapeutic use
Receptors, Adrenergic / drug effects*
Receptors, Cholinergic / drug effects*
Grant Support
2 P50 MH 30914/MH/NIMH NIH HHS
Reg. No./Substance:
0/Parasympatholytics; 0/Parasympathomimetics; 0/Receptors, Adrenergic; 0/Receptors, Cholinergic; 51-84-3/Acetylcholine; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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