| β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins. | |
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MedLine Citation:
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PMID: 21776383 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Increased sympathetic nerve activity to the myocardium is a central feature in patients with heart failure. Accumulation of catecholamines plays an important role in the pathogenesis of heart disease. Acting via β-adrenergic receptors (β-AR), catecholamines (norepinephrine and isoproterenol) increase cardiac myocyte apoptosis in vitro and in vivo. Specifically, β(1)-AR and β(2)-AR coupled to Gαs exert a proapoptotic action, while β(2)-AR coupled to Gi exerts an antiapoptotic action. β1 integrin signaling protects cardiac myocytes against β-AR-stimulated apoptosis in vitro and in vivo. Interaction of matrix metalloproteinase-2 (MMP-2) with β1 integrins interferes with the survival signals initiated by β1 integrins. This paper will discuss background information on β-AR and integrin signaling and summarize the role of β1 integrins in β-AR-stimulated cardiac myocyte apoptosis. |
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Authors:
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Parthiv Amin; Mahipal Singh; Krishna Singh |
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Publication Detail:
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Type: Journal Article Date: 2011-05-24 |
Journal Detail:
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Title: Journal of signal transduction Volume: 2011 ISSN: 2090-1747 ISO Abbreviation: J Signal Transduct Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536934 Medline TA: J Signal Transduct Country: Egypt |
Other Details:
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Languages: eng Pagination: 179057 Citation Subset: - |
Affiliation:
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Department of Physiology, James H Quillen Veterans Affairs Medical Center, James H Quillen College of Medicine, East Tennessee State University, P.O. Box 70576, Johnson City, TN 37614, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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