Document Detail


Adrenaline responsiveness in mild hypertension: no evidence for altered beta-adrenoceptor sensitivity.
MedLine Citation:
PMID:  9821849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of circulating adrenaline on cardiovascular function were studied in 14 subjects (mean age, 36.5 years; range, 19-46 years) with mild hypertension and in 14 normotensive controls, matched for age and sex. Adrenaline was infused i.v. in step-wise increasing doses (0.1, 0.2, 0.4, and 0.8 nmol/kg/min). Cardiovascular responses were evaluated by echocardiography and noninvasive blood pressure measurements. Noradrenaline, adrenaline, potassium, and cyclic adenosine monophosphate (cAMP) were determined in venous plasma. Systolic and diastolic blood pressure responses to adrenaline were similar in both groups. Adrenaline increased myocardial contractility and stroke volume, but less so in the hypertensive patients. Cardiac output was increased in the hypertensive patients at rest, but the signs of increased myocardial contractility disappeared during adrenaline infusion, most likely because of a reduced myocardial compliance. Increased heart rate and systemic vascular resistances were displayed by the hypertensive patients at all adrenaline concentrations studied, but the responses were similar in both groups. The adrenaline-induced decreases in potassium and increases in cAMP were also similar in both groups. The increases in myocardial contractility and in heart rate are compatible with an increased arousal in mild hypertension at rest. Mild hypertension does not appear to be associated with alterations of beta2-adrenoceptor sensitivity, and the findings do not support that adrenaline is involved in the pathogenesis of primary hypertension.
Authors:
T Kahan; P Hjemdahl; K Lindvall; J Ostergren; U de Faire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  32     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-9     Citation Subset:  IM    
Affiliation:
Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dose-Response Relationship, Drug
Epinephrine / blood,  pharmacology*
Female
Hemodynamics / drug effects
Humans
Hypertension / physiopathology*
Male
Middle Aged
Norepinephrine / blood
Receptors, Adrenergic, beta / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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