| Adrenalin tolerance does not prevent bacterial translocation in a murine burn model. | |
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MedLine Citation:
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PMID: 10817425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Burn injury causes mesenteric vasoconstriction and bacterial translocation. Since catecholamines are powerful vasoconstrictors and elevated immediately after burn injury, we hypothesised that adrenaline tolerance might decrease burn-induced mesenteric vasoconstriction and bacterial translocation. Adrenaline tolerance was developed in Swiss albino mice. Adrenaline tolerant and control animals were subdivided into sham-burn and burn subgroups. 24 h after sham-burn or burn injury, specimens were obtained for microbiological evaluation. Also, in a separate group of adrenaline tolerant and control animals, superior mesenteric blood flow was measured. Burn injury increased bacterial translocation rate in both control (P = 0.001) and adrenaline tolerant groups (P = 0.0351). The caecal bacterial level increase was significant after burn injury in control groups (P = 0.0004) but was not significant in adrenaline tolerant animals (P = 0.743). Mesenteric blood flow was decreased significantly by burn injury in both control and adrenaline tolerant animals (P < 0.00001). The results showed that catecholamines do not mediate postburn mesenteric vasoconstriction or bacterial translocation. |
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Authors:
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A Baykal; A B Iskit; V Kaynaroglu; M O Guc; G Hascelik; I Sayek; Y Sanac |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International surgery Volume: 85 ISSN: 0020-8868 ISO Abbreviation: Int Surg Publication Date: 2000 Jan-Mar |
Date Detail:
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Created Date: 2000-08-01 Completed Date: 2000-08-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0043524 Medline TA: Int Surg Country: ITALY |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Faculty of Medicine, University of Hacettepe, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / isolation & purification Bacterial Translocation / physiology* Burns / microbiology* Catecholamines / physiology Cecum / microbiology Drug Tolerance Epinephrine / pharmacology* Female Lymph Nodes / microbiology Mesenteric Arteries / physiopathology* Mice Vasoconstriction / physiology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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