Document Detail


Adrenalectomy reduces peripheral neural responses to gustatory stimuli in the rat.
MedLine Citation:
PMID:  2441723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the rat, sodium need leads to an increase in sodium intake, which depends on salt taste sensitivity. The adrenalectomized rat, because of excessive body sodium loss, has been an important animal model for studying the physiological mechanisms underlying salt ingestion. In order to investigate the mediation by peripheral taste responsivity of changes in salt intake, multiunit responses of the chorda tympani nerve to various concentrations of sodium chloride, potassium chloride, lithium chloride, hydrochloric acid, and quinine hydrochloride were recorded from adrenalectomized and control rats. In order to control for a generalized decrease in sensory sensitivity, recordings from the auriculotemporal nerve to tactile stimulation of the pinna were also performed. There were no group differences in amplitude of the integrated neural responses to tactile stimulation. The largest decrease in gustatory responsivity occurred for suprathreshold concentrations of sodium chloride and lithium chloride. The data are discussed with reference to possible mechanisms underlying this neural alteration and to the role that reductions in salt taste responsivity play in mediating increases in salt intake.
Authors:
T Kosten; R J Contreras
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  99     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1987-09-25     Completed Date:  1987-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  734-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / physiology*
Adrenalectomy
Animals
Chorda Tympani Nerve / physiology
Ion Channels / physiology
Male
Mandibular Nerve / physiology
Rats
Sodium Chloride*
Taste / physiology*
Taste Buds / physiology
Taste Threshold / physiology
Touch / physiology
Grant Support
ID/Acronym/Agency:
HL 28952/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ion Channels; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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