Document Detail


Adrenalectomy of the obese Zucker rat: effects on the feeding response to enterostatin and specific mRNA levels.
MedLine Citation:
PMID:  8393627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of adrenalectomy on the feeding response to enterostatin and the mRNA levels of its parent protein, pancreatic colipase, have been investigated in lean (fa/?) and genetically obese (fa/fa) rats. Adrenalectomy reduced body weight gain and food intake of obese rats. Enterostatin inhibited the intake of high-fat diet in obese rats but not in lean rats. Adrenalectomy reduced food intake of all rats and abolished the response to enterostatin in the obese group. Obese rats had low levels of colipase mRNA, but these were normalized after adrenalectomy. The ability to respond to exogenous enterostatin is possibly linked to low levels of production of the peptide. The effects of adrenalectomy on brown adipose tissue uncoupling protein (UCP) mRNA and beta 3-adrenergic receptor (beta 3-AR) mRNA were also investigated. Northern blot analysis showed low levels of both UCP mRNA and beta 3-AR mRNA in obese rats that were restored to or toward the normal levels of lean rats by adrenalectomy. Adrenalectomy had no significant effects on mRNA levels in lean rats.
Authors:
S Okada; T Onai; G Kilroy; D A York; G A Bray
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-27     Completed Date:  1993-08-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R21-7     Citation Subset:  IM    
Affiliation:
Louisiana State University, Pennington Biomedical Research Center, Baton Rouge 70808-4124.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / metabolism
Adrenalectomy*
Animals
Blotting, Northern
Body Weight
Carrier Proteins / genetics
Colipases / genetics,  pharmacology*
Eating / drug effects*
Enzyme Precursors
Ion Channels
Membrane Proteins / genetics
Mitochondrial Proteins
Obesity / pathology*,  physiopathology*
Protein Precursors / genetics,  pharmacology*
RNA, Messenger / metabolism*
Rats
Rats, Zucker
Receptors, Adrenergic, beta / genetics
Grant Support
ID/Acronym/Agency:
DK-32089/DK/NIDDK NIH HHS; DK-45278/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Colipases; 0/Enzyme Precursors; 0/Ion Channels; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/Protein Precursors; 0/RNA, Messenger; 0/Receptors, Adrenergic, beta; 0/mitochondrial uncoupling protein; 72994-53-7/procolipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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