| Adrenalectomy lowers the body weight set-point in rats. | |
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MedLine Citation:
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PMID: 9272658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the impact of a complete depletion of glucocorticoids on rats' body weight set-point, rats were adrenalectomized, and their set-points were estimated before, and after surgery. Body weight set-points were obtained from a quantitative behavioral method based on the rats' food-hoarding response to weight deficit. In addition, body fat contents were measured in vivo using a total body electrical conductivity analyzer (TOBEC). The hoarding of food showed that adrenalectomized rats had significantly lower body weight set-points than the sham-operated controls (337 +/- 11 g vs. 385 +/- 8 g) and were also significantly lighter. TOBEC measurements showed that the sham-operated control rats had a higher body fat content than the adrenalectomized rats ( 16.7 +/- 1.1% vs. 10.2 +/- 1.2%). The present study demonstrates that adrenalectomy lowers the body weight set-point in rats, suggesting that the concentrations of glucocorticoid hormones, and in turn, the hypothalamic corticotrophin releasing hormone (CRH) participates in the adjustment of the body weight set-point. |
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Authors:
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C Gosselin; M Cabanac |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 62 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 519-23 Citation Subset: IM |
Affiliation:
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Département de physiologie, Faculté de médecine, Université Laval, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy* Animals Behavior, Animal / physiology Body Weight / physiology* Energy Metabolism / physiology Male Rats Rats, Sprague-Dawley |
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