| Adrenalectomy in primary aldosteronism: a long-term follow-up study. | |
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MedLine Citation:
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PMID: 3902226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of unilateral adrenalectomy in primary aldosteronism was analyzed in 38 patients with unilateral adenoma, 12 cases with idiopathic bilateral hyperplasia and 1 patient suffering from an aldosterone-producing carcinoma. Responses to surgery differed markedly. In all 38 adenoma cases plasma aldosterone dropped to normal levels and remained within normal range during a mean follow-up period of 75 +/- 12 months. 23 (61%) of these patients became normotensive without medication and thus could be classified as definitely cured. 34% (13 patients) improved (normotensive under medical treatment) and only 2 cases (5%) remained hypertensive despite sufficient medical treatment. In the hyperplasia group, however, the effect of adrenalectomy was disappointing. None of these subjects showed a long-lasting normalization of aldosterone secretion. A temporary remission for no more than 3-4 months was achieved in only 3 patients. In a fourth case with macronodular hyperplasia, primary aldosteronism relapsed after a 6-year period of normal blood pressure and aldosterone values. Therefore, 6 years after adrenalectomy no hyperplasia patient was definitely cured in contrast to 61% of the adenoma cases. The problems in the management of hypertension in adrenal hyperplasia are furthermore documented by a poorer blood pressure control despite antihypertensive medication and a high rate of vascular complications. During the follow-up, 3 of 12 hyperplasia patients experienced a cerebrovascular event and 1 a myocardial infarction. |
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Authors:
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H Groth; W Vetter; M Stimpel; P Greminger; W Tenschert; E Klaiber; H Vetter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiology Volume: 72 Suppl 1 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1985 |
Date Detail:
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Created Date: 1985-11-25 Completed Date: 1985-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 107-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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surgery Adolescent Adrenal Gland Neoplasms / surgery Adrenal Glands / pathology Adrenalectomy* Adult Aldosterone / blood Blood Pressure Female Follow-Up Studies Humans Hyperaldosteronism / surgery* Hyperplasia Hypertension / surgery Male Middle Aged Postoperative Complications / etiology Potassium / blood Renin / blood Sodium / blood |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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