Document Detail


Adrenalectomy aggravates ischemic brain edema in female Sprague-Dawley rats with carotid arteries ligated.
MedLine Citation:
PMID:  1410408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of adrenalectomy has been investigated in a model of global cerebral ischemia. After bilateral carotid ligation the mortality rate was increased in adrenalectomized rats, and this effect was prevented by glucocorticoid pre-treatment. Adrenalectomy accelerated the appearance of the symptoms of cerebral ischemia, resulting in a moderate aggravation of brain edema and in a significant decrease in the concentration of high-energy phosphate esters. Our findings support the view that endogenous glucocorticoids may play a role in the amelioration of ischemic brain injuries in rats.
Authors:
C Abrahám; M Koltai; F Joó; A Tósaki; P Szerdahelyi
Related Documents :
2615458 - The effect of radix salviae miltiorrhizae on vasoactive intestinal peptide in cerebral ...
17210148 - The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats.
15869938 - Post-ischemic modest hypothermia (35 degrees c) combined with intravenous magnesium is ...
12865128 - Acupuncture suppresses ischemia-induced increase in c-fos expression and apoptosis in t...
6504328 - Suppression of l-dopa-induced circling in rats with nigral lesions by blockade of centr...
2882448 - Subchronic haloperidol and sulpiride treatment induces region-specific changes in tissu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  91     ISSN:  0079-6123     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenalectomy*
Animals
Brain Edema / physiopathology*
Carotid Arteries / physiology*
Dexamethasone / pharmacology*
Female
Ischemic Attack, Transient / physiopathology*
Rats
Rats, Wistar
Reference Values
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circumventricular organ capillaries.
Next Document:  Cytochemistry of CSF-contacting neurons and pinealocytes.