Document Detail

Adrenalectomy aggravates ischemic brain edema in female Sprague-Dawley rats with carotid arteries ligated.
MedLine Citation:
PMID:  1410408     Owner:  NLM     Status:  MEDLINE    
The effect of adrenalectomy has been investigated in a model of global cerebral ischemia. After bilateral carotid ligation the mortality rate was increased in adrenalectomized rats, and this effect was prevented by glucocorticoid pre-treatment. Adrenalectomy accelerated the appearance of the symptoms of cerebral ischemia, resulting in a moderate aggravation of brain edema and in a significant decrease in the concentration of high-energy phosphate esters. Our findings support the view that endogenous glucocorticoids may play a role in the amelioration of ischemic brain injuries in rats.
C Abrahám; M Koltai; F Joó; A Tósaki; P Szerdahelyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  91     ISSN:  0079-6123     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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MeSH Terms
Brain Edema / physiopathology*
Carotid Arteries / physiology*
Dexamethasone / pharmacology*
Ischemic Attack, Transient / physiopathology*
Rats, Wistar
Reference Values
Reg. No./Substance:

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