Document Detail

Adrenalectomy abolishes and cortisol restores naloxone's beneficial effects on cardiovascular function and survival in canine hemorrhagic shock.
MedLine Citation:
PMID:  6311454     Owner:  NLM     Status:  MEDLINE    
Endogenous opioid substances are activated in and may contribute to the cardiovascular depression of hemorrhagic shock. In order to determine the importance of the adrenal gland in the beneficial effects of the opiate antagonist naloxone in shock we studied 23 adrenalectomized dogs subjected to hemorrhagic shock. Adrenalectomy abolished the salubrious cardiovascular responses to naloxone. Naloxone responses (increased mean arterial pressure, cardiac output, and left ventricular contractility) were restored by giving hydrocortisone 50 mg intravenously before naloxone. Survival was also prolonged in animals receiving naloxone and hydrocortisone compared to naloxone or saline alone; hydrocortisone alone decreased survival. The adrenal glands are necessary for naloxone's beneficial effects, probably via adrenal corticosteroid secretion.
M L Patton; N J Gurll; D G Reynolds; T Vargish
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  10     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-27     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / blood
Cardiac Output / drug effects
Heart Rate / drug effects
Hydrocortisone / pharmacology*,  therapeutic use
Naloxone / pharmacology*,  therapeutic use
Postoperative Complications
Shock, Hemorrhagic / drug therapy,  mortality,  physiopathology*
Reg. No./Substance:
465-65-6/Naloxone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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