| Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy: a single-center experience. | |
| | |
MedLine Citation:
|
PMID: 19527322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Adrenal venous sampling (AVS) remains controversial in the management of primary aldosteronism. Retrospective chart review was conducted at the Hospital of the University of Pennsylvania from July 2001 to September 2007. A total of 113 patients underwent AVS, 16 patients were excluded as records were unavailable. Among 97 remaining patients, 61 had unilateral disease and 57 underwent unilateral adrenalectomy. Blood pressure (BP) improved significantly with less antihypertensive medication requirement. Among those with different BP responses to adrenalectomy (cure, improvement, or no change), a higher number of preoperative antihypertensive medications was associated with persistent hypertension (P = .03). There were no significant differences in age (P = .14), duration of hypertension (P = .60), family history of hypertension (P = .68), or serum creatinine (P = .34). When AVS shows lateralization, age, duration of hypertension, family history, or renal dysfunction did not predict BP response to adrenalectomy. Results suggest that these factors should not preclude AVS and subsequent adrenalectomy. Further studies are indicated to confirm these findings. |
| | |
Authors:
|
Miho Murashima; Scott O Trerotola; Douglas L Fraker; Dale Han; Raymond R Townsend; Debbie L Cohen |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 11 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-16 Completed Date: 2009-10-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
|
Languages: eng Pagination: 316-23 Citation Subset: IM |
Affiliation:
|
Hospital of the University of Pennsylvania, Philadelphia, 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenalectomy
/
methods* Adult Aldosterone / blood* Blood Pressure / physiology Creatinine / blood Female Humans Hyperaldosteronism / complications, diagnosis*, surgery* Hypertension / etiology, physiopathology Male Middle Aged Renin / blood* Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
52-39-1/Aldosterone; 60-27-5/Creatinine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nebivolol in obese and non-obese hypertensive patients.
Next Document: Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hy...