Document Detail

Adrenal vein catecholamines and met-enkephalin during staged hemorrhage and naltrexone administration in cats.
MedLine Citation:
PMID:  2539919     Owner:  NLM     Status:  MEDLINE    
Concurrent levels of catecholamines and met-enkephalin in adrenal vein, femoral vein, and femoral artery were measured under baseline conditions and during staged hemorrhage in halothane (1 MAC)-anesthetized cats (Group II, n = 8) and compared to a nonbled control group (Group I, n = 5). In Group III (n = 14) an i.v. bolus of naltrexone in a range of different dosages (0.01 mg/kg to 10 mg/kg) followed by a continuous infusion was administered prior to induction of hemorrhage. In Group II, the loss of 25% of estimated total blood volume led to a significant decrease (-40 +/- 11 mmHg) in mean arterial blood pressure (MABP) without evoking adrenal stimulation. Hemorrhage to 50% of total blood volume was without a further significant fall in MABP, but led to a significant increase in catecholamine and met-enkephalin levels in the adrenal vein. Naltrexone-treated cats in Group III were not different from Group II in regard to hemodynamic and sympathoadrenal response during staged hemorrhage. We conclude that prophylactic administration of naltrexone has no effect on hemodynamic parameters during staged hemorrhage and that the concurrent adrenal secretion of catecholamines and met-enkephalin is not modulated by actions on opiate receptors in the halothane-anesthetized cat.
D M Gaumann; T L Yaksh; M K Dousa; G M Tyce
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  27     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-54     Citation Subset:  IM    
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Adrenal Glands / blood supply*
Blood Pressure / drug effects
Body Weight / drug effects
Catecholamines / blood*
Chromatography, High Pressure Liquid
Enkephalin, Methionine / blood*
Epinephrine / blood
Femoral Artery / metabolism
Femoral Vein / metabolism
Hemorrhage / blood*,  drug therapy
Naltrexone / therapeutic use*
Norepinephrine / blood
Receptors, Opioid / physiology
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Opioid; 16590-41-3/Naltrexone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 58569-55-4/Enkephalin, Methionine

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