Document Detail

Adrenal suppression following intralesional corticosteroids for periocular haemangiomas.
MedLine Citation:
PMID:  21321258     Owner:  NLM     Status:  Publisher    
Background/aims Treatment with intralesional triamcinolone/betamethasone is recommended for infantile sight-threatening periocular haemangiomas. This study investigates the endocrine and weight changes in 15 infants undergoing therapy over 12 years. Methods 15 infants, median age 19 weeks (range 10-56) receiving intra/perilesional triamcinolone/betamethasone underwent serial measurement of weight, early morning serum cortisol and adrenocorticotropic hormone (ACTH) before and after injection. Results Cortisol fell from a median (range) of 383 (112-594) to 28 (<10-506) nmol/l (p=0.005) and ACTH from 26 (14-134) to 9 (5-20) ng/l (p=0.05) from before injection to 4 weeks after treatment. Prolonged adrenal suppression occurred in 13 out of 15 cases with time to recovery being 19.5 (4-65) weeks. Failure to gain weight appropriately was observed in 14 infants but recovered once normal adrenal function was re-established. Conclusion Prolonged adrenal suppression following triamcinolone/betamethasone injection for periocular haemangiomas is common and associated with faltering weight gain.
C Morkane; J W Gregory; P Watts; J T Warner
Related Documents :
18572248 - Mothers with depressive symptoms: cross-situational consistency and temporal stability ...
7752048 - Temperament of the infant with myelomeningocele.
3195358 - Offspring of women with nonorganic psychosis: mother-infant interaction and fear of str...
7971298 - Maternal-infant attachment of experienced and inexperienced mothers during infancy.
11696148 - Regional anaesthesia decreases the need for postoperative mechanical ventilation in ver...
19490748 - Segmental production in mandarin-learning infants.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-14
Journal Detail:
Title:  Archives of disease in childhood     Volume:  -     ISSN:  1468-2044     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiff University, Cardiff, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a populat...
Next Document:  Micro-SPECT/CT-Based Pharmacokinetic Analysis of 99mTc-Diethylenetriaminepentaacetic Acid in Rats wi...