Document Detail

Adrenal steroids in maternal and cord blood after dexamethasone administration at midterm.
MedLine Citation:
PMID:  2997263     Owner:  NLM     Status:  MEDLINE    
We undertook a study designed to evaluate whether it is feasible to suppress fetal adrenal secretion of androgens at mid-pregnancy by giving dexamethasone (DX) to the mother. Levels of DX and adrenal steroids were measured in maternal and cord plasma of 13 DX-treated and 16 untreated mothers undergoing abortion at 18-20 weeks of pregnancy. Maternal adrenal suppression was evidenced by a sharp fall of plasma cortisol (F), cortisone (E), corticosterone (B), and dehydroepiandrosterone sulfate (DHEA-S). However, in cord blood no fall of DHEA-S or corticosterone sulfate (BS) was found up to 20 hours after DX administration, and cord plasma ACTH remained detectable. The failure of DX to suppress the fetal adrenal at mid-pregnancy suggests that this drug would not be effective in the intrauterine treatment of congenital adrenal hyperplasia (C.A.H.).
S Charnvises; M D Fencl; R Osathanondh; M G Zhu; R Underwood; D Tulchinsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  61     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1985-12-13     Completed Date:  1985-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1220-2     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenal Cortex Hormones / blood*
Adrenocorticotropic Hormone / blood
Corticosterone / blood
Cortisone / blood
Dehydroepiandrosterone / analogs & derivatives,  blood
Dehydroepiandrosterone Sulfate
Dexamethasone / blood,  pharmacology*
Fetal Blood / analysis*
Gestational Age
Hydrocortisone / blood
Maternal-Fetal Exchange
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 53-06-5/Cortisone; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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