| Adrenal steroids in maternal and cord blood after dexamethasone administration at midterm. | |
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MedLine Citation:
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PMID: 2997263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We undertook a study designed to evaluate whether it is feasible to suppress fetal adrenal secretion of androgens at mid-pregnancy by giving dexamethasone (DX) to the mother. Levels of DX and adrenal steroids were measured in maternal and cord plasma of 13 DX-treated and 16 untreated mothers undergoing abortion at 18-20 weeks of pregnancy. Maternal adrenal suppression was evidenced by a sharp fall of plasma cortisol (F), cortisone (E), corticosterone (B), and dehydroepiandrosterone sulfate (DHEA-S). However, in cord blood no fall of DHEA-S or corticosterone sulfate (BS) was found up to 20 hours after DX administration, and cord plasma ACTH remained detectable. The failure of DX to suppress the fetal adrenal at mid-pregnancy suggests that this drug would not be effective in the intrauterine treatment of congenital adrenal hyperplasia (C.A.H.). |
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Authors:
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S Charnvises; M D Fencl; R Osathanondh; M G Zhu; R Underwood; D Tulchinsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 61 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1985-12-13 Completed Date: 1985-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1220-2 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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blood* Adrenocorticotropic Hormone / blood Corticosterone / blood Cortisone / blood Dehydroepiandrosterone / analogs & derivatives, blood Dehydroepiandrosterone Sulfate Dexamethasone / blood, pharmacology* Female Fetal Blood / analysis* Gestational Age Humans Hydrocortisone / blood Maternal-Fetal Exchange Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 53-06-5/Cortisone; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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