Document Detail


Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm.
MedLine Citation:
PMID:  21388405     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral clock, are also involved. GC regulates diverse physiological processes and acts as a signal for resetting peripheral clocks, which suggests the importance of the GC rhythm in harmonizing overall circadian physiology and behavior. Therefore, in this review, we will discuss the important role of the adrenal peripheral clockwork in the circadian regulation of GC and its physiological relevance in the circadian timing system.
Authors:
Sooyoung Chung; Gi Hoon Son; Kyungjin Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1220     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
Affiliation:
Department of Biological Sciences, Seoul National University and Brain Research Center for the 21st Century Frontier Program in Neuroscience, Seoul, Korea.
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