| Adrenal medullary responses to repeated hemorrhage in the anesthetized dog. | |
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MedLine Citation:
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PMID: 7140640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenal secretory rates of catecholamines in response to a repeated stimulus have not been described. We have used repeated small hemorrhages spaced 24 h apart in pentobarbital anesthetized dogs prepared with a chronic adrenal venous catheter to study this question. Our results confirm earlier reports that an initial 7.5 ml/kg hemorrhage is a mild stimulus to the adrenal medullar secretion of epinephrine and norepinephrine, However, when this stimulus is repeated 24 h later, a greatly potentiated secretory response of both hormones is seen. Cardiovascular changes after hemorrhage did not differ on the 2 days. Repeated 3.75 ml/kg hemorrhages did not lead to augmented adrenal medullary secretion of catecholamines on day 2. These data indicate that there is a factor associated with hemorrhage that potentiates the adrenal medullary response to second small hemorrhage. This factor appears to be subject to a threshold that lies between a 3.75 and 7.5 ml/kg hemorrhage. A significant catecholamine response on day 1 was not essential for the potentiated response on day 2. Thus, this phenomenon does not appear to be the result of adrenal enzyme induction as a consequence of prior adrenal medullary stimulation. |
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Authors:
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M P Lilly; W C Engeland; D S Gann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 111 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1917-24 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Diseases
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physiopathology Adrenal Medulla / physiopathology* Animals Blood Pressure Dogs Epinephrine / secretion Female Heart Rate Hemorrhage / physiopathology* Male Norepinephrine / secretion Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AM-26831/AM/NIADDK NIH HHS; GM-27946/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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