| Adrenal incidentalomas: risk of adrenocortical carcinoma and clinical outcomes. | |
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MedLine Citation:
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PMID: 20734420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The number of incidentally discovered adrenal lesions is increasing due to the widespread use of abdominal imaging. Although most incidentalomas are benign, larger suspicious lesions will require adrenalectomy. The aim of this study is to determine the risk of malignancy in patients undergoing surgery for adrenal incidentaloma; and to compare clinical outcomes in those with adrenocortical carcinoma (ACC) based on the mode of presentation. METHODS: A retrospective study of consecutive patients who underwent adrenalectomy between 1995 and 2008 was performed. Data were retrieved from a prospectively maintained adrenal tumor database. Those with adrenal incidentaloma were selected and histopathology reviewed. All patients with ACC (presenting with symptoms or incidentally) during the same time period were identified and clinical outcomes compared. RESULTS: Adrenalectomy was performed in 274 patients of whom 73 (27%) were characterized pre-operatively as incidentaloma. Benign, non-functioning adrenocortical adenoma was the most common histopathological finding (46 patients, 63%). There was a trend (P = 0.08) towards increased survival amongst the seven patients with ACC presenting incidentally compared to the nine patients with symptomatic ACC. CONCLUSIONS: Adrenal incidentalomas have a small but important risk of malignancy. ACC presenting as incidentaloma appear to have a more favorable prognosis than symptomatic or functioning ACC. |
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Authors:
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Christine J O'Neill; Andrew Spence; Barney Logan; James W Suliburk; Patsy S Soon; Diana L Learoyd; Stan B Sidhu; Mark S Sywak |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of surgical oncology Volume: 102 ISSN: 1096-9098 ISO Abbreviation: J Surg Oncol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 450-3 Citation Subset: IM |
Copyright Information:
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J. Surg. Oncol. 2010;102:450-453. © 2010 Wiley-Liss, Inc. |
Affiliation:
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University of Sydney Endocrine Surgical Unit, St. Leonards, New South Wales, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Neoplasms / pathology*, surgery Adrenalectomy Adrenocortical Carcinoma / pathology*, surgery Adult Aged Humans Incidental Findings* Kaplan-Meiers Estimate Middle Aged Prognosis Retrospective Studies Risk Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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