Document Detail

Adrenal hypofunction and trisomy 18.
MedLine Citation:
PMID:  6700888     Owner:  NLM     Status:  MEDLINE    
Three cases of trisomy 18 are described, each with evidence of diminished fetoplacental function, specifically reduced 24-hour maternal urinary estrogen. All three infants died within three months and showed gross and microscopic evidence of hypoplasia of the fetal adrenal cortical zone. This abnormality is consistent with and helps explain the increased incidence of obstetric intervention and prolonged pregnancy in this syndrome.
M Turner; C O'Herlihy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  63     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-03-27     Completed Date:  1984-03-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84S-85S     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Multiple / diagnosis*
Adrenal Glands / abnormalities*
Adrenal Insufficiency / diagnosis*,  etiology
Chromosomes, Human, 16-18*
Estrogens / urine
Fetal Diseases / etiology
Infant, Newborn
Reg. No./Substance:

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