Document Detail

Adrenal glands and testes as steroidogenic tissue are affected by retinoylation reaction.
MedLine Citation:
PMID:  19521754     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to better understand the physiological role of the retinoylation process in steroidogenic tissues. In adrenal gland mitochondria, the retinoylation extent was found equal to that of testes mitochondria but without ATP in the incubation buffer. We pointed out that the endogenous mitochondrial ATP in adrenal glands is much higher than in testes, about 1.3 x 10(-2) M and 5.2 x 10(-8) M, respectively. In addition, less CoASH is required for the maximal acylation activity of the retinoyl moiety to protein(s) compared to testes. The fatty acid analysis revealed a different composition of mitochondrial membranes of these two tissues. Among the different values of fatty acids, it is important to note that adrenal glands contain a much higher amount of C18:0 and a much lower amount of C22:5 omega6 and C22:6 omega3 than testes in the mitochondrial membranes. In addition, there were also differences in arachidonic acid (ARA, C20:4 omega6) content between adrenal glands and testes mitochondria. These different values in the fatty acids composition should explain the different extent of the retinoylation process between the two organs.
Attilio Pingitore; Erika Cione; Valentina Senatore; Giuseppe Genchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-12
Journal Detail:
Title:  Journal of bioenergetics and biomembranes     Volume:  41     ISSN:  1573-6881     ISO Abbreviation:  J. Bioenerg. Biomembr.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701859     Medline TA:  J Bioenerg Biomembr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  IM    
Department of Pharmaco-Biology, University of Calabria, CS, Italia.
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MeSH Terms
Adenosine Triphosphate / metabolism
Adrenal Glands / metabolism*
Arachidonic Acid / metabolism
Fatty Acids / analysis
Mitochondria / metabolism*
Mitochondrial Membranes / chemistry
Proteins / metabolism*
Testis / metabolism*
Tretinoin / metabolism*
Reg. No./Substance:
0/Fatty Acids; 0/Proteins; 302-79-4/Tretinoin; 506-32-1/Arachidonic Acid; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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