Document Detail

Adrenal gland volume measurement in septic shock and control patients: a pilot study.
MedLine Citation:
PMID:  20521055     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare adrenal gland volume in septic shock patients and control patients by using semi-automated volumetry.
METHODS: Adrenal gland volume and its inter-observer variability were measured with tomodensitometry using semi-automated software in 104 septic shock patients and in 40 control patients. The volumes of control and septic shock patients were compared and the relationship between volume and outcome in intensive care was studied.
RESULTS: The mean total volume of both adrenal glands was 7.2 ± 2.0 cm(3) in control subjects and 13.3 ± 4.7 cm(3) for total adrenal gland volume in septic shock patients (p < 0.0001). Measurement reproducibility was excellent with a concordance correlation coefficient value of 0.87. The increasing adrenal gland volume was associated with a higher rate of survival in intensive care.
CONCLUSION: The present study reports that with semi-automated software, adrenal gland volume can be measured easily and reproducibly. Adrenal gland volume was found to be nearly double in sepsis compared with control patients. The absence of increased volume during sepsis would appear to be associated with a higher rate of mortality and may represent a prognosis factor which may help the clinician to guide their strategy.
Stephanie Nougaret; B Jung; S Aufort; G Chanques; S Jaber; B Gallix
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Publication Detail:
Type:  Journal Article     Date:  2010-06-04
Journal Detail:
Title:  European radiology     Volume:  20     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2348-57     Citation Subset:  IM    
Department of Abdominal Imaging, CHU Montpellier, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
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MeSH Terms
Adrenal Glands / pathology*
Case-Control Studies
Densitometry / methods
Middle Aged
Pilot Projects
Reproducibility of Results
Shock, Septic / pathology*
Tomography, X-Ray Computed / methods

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