| Adrenal function status in patients with paracoccidioidomycosis after prolonged post-therapy follow-up. | |
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MedLine Citation:
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PMID: 20595488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed adrenal function in patients with paracoccididioidomycosis who had been treated to determine a possible connection between high antibody titers and adrenal dysfunction attributable to persistence of the fungus in adrenal gland. Adrenal gland function was studied in 28 previously treated patients, 2 (7.1%) of whom were shown to have adrenal insufficiency and 7 (259%) who showed a below normal response to stimuli by adrenocorticotropic hormone. Paracoccidioides brasiliensis was detected in the adrenal gland from one of the patients with adrenal insufficiency. Although the study failed to demonstrate a significant difference between high antibody titers and low cortisol levels, the proportion of adrenal insufficiency detected and the subnormal response to adrenocorticotropic hormone confirmed that adrenal damage is an important sequela of paracoccidioidomycosis. Studies with a larger number of patients should be conducted to confirm the hypothesis of persistence of P. brasiliensis in adrenal gland after therapy. |
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Authors:
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Angela M Tobón; Carlos A Agudelo; Carlos A Restrepo; Carlos A Villa; William Quiceno; Santiago Estrada; Angela Restrepo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 83 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-08-10 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 111-4 Citation Subset: AIM; IM |
Affiliation:
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Medical and Experimental Mycology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects*,
physiopathology Adrenal Insufficiency / chemically induced*, etiology Algorithms Drug Therapy, Combination / adverse effects* Follow-Up Studies Humans Hydrocortisone / toxicity* Paracoccidioides / drug effects* Paracoccidioidomycosis / drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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