Document Detail


Adrenal function status in patients with paracoccidioidomycosis after prolonged post-therapy follow-up.
MedLine Citation:
PMID:  20595488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed adrenal function in patients with paracoccididioidomycosis who had been treated to determine a possible connection between high antibody titers and adrenal dysfunction attributable to persistence of the fungus in adrenal gland. Adrenal gland function was studied in 28 previously treated patients, 2 (7.1%) of whom were shown to have adrenal insufficiency and 7 (259%) who showed a below normal response to stimuli by adrenocorticotropic hormone. Paracoccidioides brasiliensis was detected in the adrenal gland from one of the patients with adrenal insufficiency. Although the study failed to demonstrate a significant difference between high antibody titers and low cortisol levels, the proportion of adrenal insufficiency detected and the subnormal response to adrenocorticotropic hormone confirmed that adrenal damage is an important sequela of paracoccidioidomycosis. Studies with a larger number of patients should be conducted to confirm the hypothesis of persistence of P. brasiliensis in adrenal gland after therapy.
Authors:
Angela M Tobón; Carlos A Agudelo; Carlos A Restrepo; Carlos A Villa; William Quiceno; Santiago Estrada; Angela Restrepo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  83     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-08-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  AIM; IM    
Affiliation:
Medical and Experimental Mycology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects*,  physiopathology
Adrenal Insufficiency / chemically induced*,  etiology
Algorithms
Drug Therapy, Combination / adverse effects*
Follow-Up Studies
Humans
Hydrocortisone / toxicity*
Paracoccidioides / drug effects*
Paracoccidioidomycosis / drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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