Document Detail

Adrenal function and the incidence of bends after decompression in mice: effect of adrenalectomy, corticosteroids, decompression intensity, and time of day.
MedLine Citation:
PMID:  531995     Owner:  NLM     Status:  MEDLINE    
The adrenocortical endocrine subsystem has been demonstrated to enhance mammalian tolerance to harsh environmental conditions, including hypoxia and temperature extremes. In a series of factorial experiments, mice were exposed to one of three elevated hydrostatic pressures for 30 min and then decompressed (0.75 atm/s). It was demonstrated that 1) tolerance to decompression does not differ significantly (P greater than 0.3) in surgically intact, sham adrenalectomized, or in adrenalectomized animals; 2) intraperitoneal administration of pharmacologic doses (0.4, 1.0, and 2.0 mg/mouse) or corticosterone or deoxycorticosterone acetate does not significantly enhance (P greater than 0.1) survivorship when compared to vehicle-injected controls; and 3) the incidence of decompression sickness (DS) does not fluctuate with time of day (P greater than 0.4). In a fourth study, the plasma concentration of corticosterone was quantitated in 1) colony control mice, 2) mice exposed to the 1-ATA chamber environment (chamber control), or 3) mice compressed to 3, 5, 7, 9, or 11 ATA and then decompressed. In general, plasma corticosterone in symptom-free mice was elevated approximately threefold (P less than 0.05) by exposure to the 1-ATA chamber environment and by decompression from 3 to 11 ATA. At 11 ATA, plasma corticosterone levels in decompressed mice exhibiting decompression sickness symptoms were significantly elevated (P less than 0.05) compared to the levels observed in decompressed symptom-free mice. These studies indicate that adrenocortical function does not enhance tolerance to decompression in mice.
B A Rattner; S P Gruenau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Undersea biomedical research     Volume:  6     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1980-04-23     Completed Date:  1980-04-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-66     Citation Subset:  IM; S    
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MeSH Terms
Adrenal Cortex Hormones / pharmacology*
Adrenal Glands / physiology*
Circadian Rhythm
Corticosterone / blood
Decompression Sickness / etiology*,  prevention & control
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-22-6/Corticosterone

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