Document Detail

Adrenal cortical carcinomas with myxoid differentiation in the domestic ferret (Mustela putorius furo).
MedLine Citation:
PMID:  12637752     Owner:  NLM     Status:  MEDLINE    
A total of 15 adrenocortical carcinomas with myxoid differentiation from 15 ferrets were evaluated in this retrospective study. Six of these ferrets (40%) either were euthanatized or died due to invasive and/or metastatic disease. The myxoid component was a variable part (between 5% and 95%) of the adrenal cortical neoplasm and consisted of sheets and cords of small, polygonal neoplastic cells that formed lumenlike spaces. Such spaces contained a variable amount of alcian blue (pH 2.5)-positive mucinous product (i.e., acidic mucopolysaccharides). Neoplastic cells were negative for the argentaffin reaction, but immunohistochemically they were strongly positive for vimentin and alpha-inhibin and lightly positive for synaptophysin. Proliferating cell nuclear antigen (PCNA)-labeling indices (LI) of adrenal cortical neoplastic cells within the myxoid component of the neoplasm were significantly elevated (P < 0.05) compared with those of typical neoplastic adrenal cortical cells or the adjacent nonneoplastic zona reticularis. Ultrastructurally, cells in the myxoid component exhibited a typical adrenocortical phenotype characterized by cytoplasmic lipid vacuoles, prominent rough and smooth endoplasmic reticulum, and zonula adherens. This lesion was interpreted as an adrenal cortical carcinoma with myxoid differentiation and appeared to be highly malignant based on PCNA LI, rate of invasion into adjacent tissue, and metastasis (6/15). This report is the first description of this histologic variant in the ferret, which morphologically resembled the rare myxoid variant of adrenocortical carcinoma described in humans.
R A Peterson; M Kiupel; C C Capen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  40     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-42     Citation Subset:  IM    
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Adrenal Cortex Neoplasms / pathology,  veterinary*
Adrenocortical Carcinoma / pathology,  veterinary*
Immunohistochemistry / veterinary
Inhibins / metabolism
Microscopy, Electron
Myxoma / pathology,  veterinary*
Proliferating Cell Nuclear Antigen / metabolism
Retrospective Studies
Synaptophysin / metabolism
Vimentin / metabolism
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 0/Synaptophysin; 0/Vimentin; 0/inhibin-alpha subunit; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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